Carrara, Marta and Prischi, Filippo and Ali, Maruf (2013) UPR Signal Activation by Luminal Sensor Domains. International Journal of Molecular Sciences, 14 (3). pp. 6454-6466. DOI https://doi.org/10.3390/ijms14036454
Carrara, Marta and Prischi, Filippo and Ali, Maruf (2013) UPR Signal Activation by Luminal Sensor Domains. International Journal of Molecular Sciences, 14 (3). pp. 6454-6466. DOI https://doi.org/10.3390/ijms14036454
Carrara, Marta and Prischi, Filippo and Ali, Maruf (2013) UPR Signal Activation by Luminal Sensor Domains. International Journal of Molecular Sciences, 14 (3). pp. 6454-6466. DOI https://doi.org/10.3390/ijms14036454
Abstract
<jats:p>The unfolded protein response (UPR) is a cell-signaling system that detects the accumulation of unfolded protein within the endoplasmic reticulum (ER) and initiates a number of cellular responses to restore ER homeostasis. The presence of unfolded protein is detected by the ER-luminal sensor domains of the three UPR-transducer proteins IRE1, PERK, and ATF6, which then propagate the signal to the cytosol. In this review, we discuss the various mechanisms of action that have been proposed on how the sensor domains detect the presence of unfolded protein to activate downstream UPR signaling.</jats:p>
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | unfolded protein response; ER-stress; signaling |
| Subjects: | Q Science > Q Science (General) |
| Divisions: | Faculty of Science and Health Faculty of Science and Health > Life Sciences, School of |
| SWORD Depositor: | Unnamed user with email elements@essex.ac.uk |
| Depositing User: | Unnamed user with email elements@essex.ac.uk |
| Date Deposited: | 15 Jan 2016 14:12 |
| Last Modified: | 30 Oct 2024 20:39 |
| URI: | http://repository.essex.ac.uk/id/eprint/15856 |
Available files
Filename: ijms-14-06454.pdf
Licence: Creative Commons: Attribution 3.0