Hay, Debbie L and Walker, Christopher S and Gingell, Joseph J and Ladds, Graham and Reynolds, Christopher A and Poyner, David R (2016) Receptor activity-modifying proteins; multifunctional G protein-coupled receptor accessory proteins. Biochemical Society Transactions, 44 (2). pp. 568-573. DOI https://doi.org/10.1042/BST20150237
Hay, Debbie L and Walker, Christopher S and Gingell, Joseph J and Ladds, Graham and Reynolds, Christopher A and Poyner, David R (2016) Receptor activity-modifying proteins; multifunctional G protein-coupled receptor accessory proteins. Biochemical Society Transactions, 44 (2). pp. 568-573. DOI https://doi.org/10.1042/BST20150237
Hay, Debbie L and Walker, Christopher S and Gingell, Joseph J and Ladds, Graham and Reynolds, Christopher A and Poyner, David R (2016) Receptor activity-modifying proteins; multifunctional G protein-coupled receptor accessory proteins. Biochemical Society Transactions, 44 (2). pp. 568-573. DOI https://doi.org/10.1042/BST20150237
Abstract
Receptor activity-modifying proteins (RAMPs) are single pass membrane proteins initially identified by their ability to determine the pharmacology of the calcitonin receptor-like receptor (CLR), a family B G protein-coupled receptor (GPCR). It is now known that RAMPs can interact with a much wider range of GPCRs. This review considers recent developments on the structure of the complexes formed between the extracellular domains (ECDs) of CLR and RAMP1 or RAMP2 as these provide insights as to how the RAMPs direct ligand binding. The range of RAMP interactions is also considered; RAMPs can interact with numerous family B GPCRs as well as examples of family A and family C GPCRs. They influence receptor expression at the cell surface, trafficking, ligand binding and G protein coupling. The GPCR–RAMP interface offers opportunities for drug targeting, illustrated by examples of drugs developed for migraine.
Item Type: | Article |
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Uncontrolled Keywords: | adrenomedullin,amylin,calcitonin gene-related peptide (CGRP),calcitonin receptor,calcitonin receptor-like receptor,family B G protein-coupled receptor,receptor activity-modifying protein (RAMP),Biochemistry |
Subjects: | Q Science > QH Natural history > QH301 Biology |
Divisions: | Faculty of Science and Health Faculty of Science and Health > Life Sciences, School of |
SWORD Depositor: | Unnamed user with email elements@essex.ac.uk |
Depositing User: | Unnamed user with email elements@essex.ac.uk |
Date Deposited: | 12 Jul 2016 14:39 |
Last Modified: | 07 Aug 2024 19:54 |
URI: | http://repository.essex.ac.uk/id/eprint/17124 |