Litthauer, Suzanne and Chan, Kai Xun and Jones, Matthew Alan (2018) 3'-Phosphoadenosine 5'-Phosphate Accumulation Delays the Circadian System. Plant Physiology, 176 (4). pp. 3120-3135. DOI https://doi.org/10.1104/pp.17.01611
Litthauer, Suzanne and Chan, Kai Xun and Jones, Matthew Alan (2018) 3'-Phosphoadenosine 5'-Phosphate Accumulation Delays the Circadian System. Plant Physiology, 176 (4). pp. 3120-3135. DOI https://doi.org/10.1104/pp.17.01611
Litthauer, Suzanne and Chan, Kai Xun and Jones, Matthew Alan (2018) 3'-Phosphoadenosine 5'-Phosphate Accumulation Delays the Circadian System. Plant Physiology, 176 (4). pp. 3120-3135. DOI https://doi.org/10.1104/pp.17.01611
Abstract
The circadian system optimizes cellular responses to stress, but the signaling pathways that convey the metabolic consequences of stress into this molecular timekeeping mechanism remain unclear. Redox regulation of the SAL1 phosphatase during abiotic stress initiates a signaling pathway from chloroplast to nucleus by regulating the accumulation of a metabolite, 3'-phosphoadenosine 5'-phosphate (PAP). Consequently, PAP accumulates in response to redox stress and inhibits the activity of exoribonucleases (XRNs) in the nucleus and cytosol. We demonstrated that osmotic stress induces a lengthening of circadian period and that genetically inducing the SAL1-PAP-XRN pathway in plants lacking either SAL1 or XRNs similarly delays the circadian system. Exogenous application of PAP was also sufficient to extend circadian period. Thus, SAL1-PAP-XRN signaling likely regulates circadian rhythms in response to redox stress. Our findings exemplify how two central processes in plants, molecular timekeeping and responses to abiotic stress, can be interlinked to regulate gene expression.
Item Type: | Article |
---|---|
Uncontrolled Keywords: | Plants, Genetically Modified; Arabidopsis; Exoribonucleases; Phosphoric Monoester Hydrolases; Adenosine Diphosphate; Signal Transduction; Gene Expression Regulation, Plant; Oxidation-Reduction; Circadian Rhythm; Mutation; Osmotic Pressure; Stress, Physiological |
Subjects: | Q Science > QH Natural history > QH301 Biology |
Divisions: | Faculty of Science and Health Faculty of Science and Health > Life Sciences, School of |
SWORD Depositor: | Unnamed user with email elements@essex.ac.uk |
Depositing User: | Unnamed user with email elements@essex.ac.uk |
Date Deposited: | 19 Apr 2018 14:17 |
Last Modified: | 07 Aug 2024 18:40 |
URI: | http://repository.essex.ac.uk/id/eprint/21564 |
Available files
Filename: pp.17.01611.full.pdf