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Short-term and spike-timing-dependent plasticity facilitate the formation of modular neural networks

Lameu, EL and Borges, FS and Iarosz, KC and Protachevicz, PR and Antonopoulos, CG and Macau, EEN and Batista, AM (2021) 'Short-term and spike-timing-dependent plasticity facilitate the formation of modular neural networks.' Communications in Nonlinear Science and Numerical Simulation, 96. ISSN 1007-5704

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Abstract

The brain has the phenomenal ability to reorganise itself by forming new connections among neurons and by pruning others. The so-called neural or brain plasticity facilitates the modification of brain structure and function over different time scales. Plasticity might occur due to external stimuli received from the environment, during recovery from brain injury, or due to modifications within the body and brain itself. In this paper, we study the combined effect of short-term (STP) and spike-timing-dependent plasticity (STDP) on the synaptic strength of excitatory coupled Hodgkin-Huxley neurons and show that plasticity can facilitate the formation of modular neural networks with complex topologies that resemble those of networks with preferential attachment properties. In particular, we use an STDP rule that alters the synaptic coupling intensity based on time intervals between spikes of postsynaptic and presynaptic neurons. Previous work has shown that STDP may induce the emergence of directed connections from high to low frequency spiking neurons. On the other hand, STP is attributed to the release of neurotransmitters in the synaptic cleft of neurons that alter its synaptic efficiency. Our results suggest that the combined effect of STP and STDP with long recovery times facilitates the formation of connections among neurons with similar spike frequencies only, a kind of preferential attachment. We then pursue this further and show that, when starting with all-to-all neural configurations, depending on the STP recovery time and distribution of neural frequencies, modular neural networks can emerge as a direct result of the combined effect of STP and STDP.

Item Type: Article
Divisions: Faculty of Science and Health > Mathematical Sciences, Department of
Depositing User: Elements
Date Deposited: 26 Nov 2019 12:05
Last Modified: 05 May 2021 08:15
URI: http://repository.essex.ac.uk/id/eprint/26024

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