Hatlen, Andrea and Helmy, Mohab and Marco, Antonio (2019) PopTargs: a database for studying population evolutionary genetics of human microRNA target sites. Database, 2019 (1). DOI https://doi.org/10.1093/database/baz102
Hatlen, Andrea and Helmy, Mohab and Marco, Antonio (2019) PopTargs: a database for studying population evolutionary genetics of human microRNA target sites. Database, 2019 (1). DOI https://doi.org/10.1093/database/baz102
Hatlen, Andrea and Helmy, Mohab and Marco, Antonio (2019) PopTargs: a database for studying population evolutionary genetics of human microRNA target sites. Database, 2019 (1). DOI https://doi.org/10.1093/database/baz102
Abstract
There is an increasing interest in the study of polymorphic variants at gene regulatory motifs, including microRNA target sites. Understanding the effects of selective forces at specific microRNA target sites, together with other factors like expression levels or evolutionary conservation, requires the joint study of multiple datasets. We have compiled information from multiple sources and compared it with predicted microRNA target sites to build a comprehensive database for the study of microRNA targets in human populations. PopTargs is a web-based tool that allows the easy extraction of multiple datasets and the joint analyses of them, including allele frequencies, ancestral status, population differentiation statistics and site conservation. The user can also compare the allele frequency spectrum between two groups of target sites and conveniently produce plots. The database can be easily expanded as new data becomes available and the raw database as well as code for creating new custom-made databases is available for downloading. We also describe a few illustrative examples.
Item Type: | Article |
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Uncontrolled Keywords: | Alleles; Databases, Nucleic Acid; Gene Frequency; Human Genetics; Humans; Internet; MicroRNAs |
Divisions: | Faculty of Science and Health Faculty of Science and Health > Life Sciences, School of |
SWORD Depositor: | Unnamed user with email elements@essex.ac.uk |
Depositing User: | Unnamed user with email elements@essex.ac.uk |
Date Deposited: | 16 Jul 2021 12:59 |
Last Modified: | 07 Aug 2024 20:43 |
URI: | http://repository.essex.ac.uk/id/eprint/26412 |
Available files
Filename: PopTargs a database for studying population evolutionary genetics of human microRNA target sites.pdf
Licence: Creative Commons: Attribution 3.0