Papanastasiou, G and Williams, MC and Dweck, MR and Mirsadraee, S and Weir, N and Fletcher, A and Lucatelli, C and Patel, D and van Beek, EJR and Newby, DE and Semple, SIK (2018) Multimodality Quantitative Assessments of Myocardial Perfusion Using Dynamic Contrast Enhanced Magnetic Resonance and 15O-Labeled Water Positron Emission Tomography Imaging. IEEE Transactions on Radiation and Plasma Medical Sciences, 2 (3). pp. 259-271. DOI https://doi.org/10.1109/trpms.2018.2796626
Papanastasiou, G and Williams, MC and Dweck, MR and Mirsadraee, S and Weir, N and Fletcher, A and Lucatelli, C and Patel, D and van Beek, EJR and Newby, DE and Semple, SIK (2018) Multimodality Quantitative Assessments of Myocardial Perfusion Using Dynamic Contrast Enhanced Magnetic Resonance and 15O-Labeled Water Positron Emission Tomography Imaging. IEEE Transactions on Radiation and Plasma Medical Sciences, 2 (3). pp. 259-271. DOI https://doi.org/10.1109/trpms.2018.2796626
Papanastasiou, G and Williams, MC and Dweck, MR and Mirsadraee, S and Weir, N and Fletcher, A and Lucatelli, C and Patel, D and van Beek, EJR and Newby, DE and Semple, SIK (2018) Multimodality Quantitative Assessments of Myocardial Perfusion Using Dynamic Contrast Enhanced Magnetic Resonance and 15O-Labeled Water Positron Emission Tomography Imaging. IEEE Transactions on Radiation and Plasma Medical Sciences, 2 (3). pp. 259-271. DOI https://doi.org/10.1109/trpms.2018.2796626
Abstract
Kinetic modeling of myocardial perfusion imaging data allows the absolute quantification of myocardial blood flow (MBF) and can improve the diagnosis and clinical assessment of coronary artery disease (CAD). Positron emission tomography (PET) imaging is considered the reference standard technique for absolute quantification, whilst oxygen-15 (15O)-water has been extensively implemented for MBF quantification. Dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) has also been used for MBF quantification and showed comparable diagnostic performance against (¹⁵ O)-water PET studies. We investigated for the first time the diagnostic performance of two different PET MBF analysis softwares PMOD and Carimas, for obstructive CAD detection against invasive clinical standard methods in 20 patients with known or suspected CAD. Fermi and distributed parameter modeling-derived MBF quantification from DCE-MRI was also compared against (15O)-water PET, in a subgroup of six patients. The sensitivity and specificity for PMOD was significantly superior for obstructive CAD detection in both per vessel (0.83, 0.90) and per patient (0.86, 0.75) analysis, against Carimas (0.75, 0.65) and (0.81, 0.70), respectively. We showed strong, significant correlations between MR and PET MBF quantifications (r = 0.83 - 0.92). However, DP and PMOD analysis demonstrated comparable and higher hemodynamic differences between obstructive versus (no, minor, or non)-obstructive CAD, against Fermi and Carimas analysis. Our MR method assessments against the optimum PET reference standard technique for perfusion analysis showed promising results in per segment level and can support further multimodality assessments in larger patient cohorts. Further MR against PET assessments may help to determine their comparative diagnostic performance for obstructive CAD detection.
Item Type: | Article |
---|---|
Uncontrolled Keywords: | Coronary artery disease (CAD); dynamic contrast enhanced magnetic resonance imaging (DCE-MRI); kinetic modeling; Oxygen-15 (O-15)-water Positron emission tomography (PET) |
Divisions: | Faculty of Science and Health Faculty of Science and Health > Computer Science and Electronic Engineering, School of |
SWORD Depositor: | Unnamed user with email elements@essex.ac.uk |
Depositing User: | Unnamed user with email elements@essex.ac.uk |
Date Deposited: | 22 Jul 2020 14:57 |
Last Modified: | 07 Aug 2024 16:19 |
URI: | http://repository.essex.ac.uk/id/eprint/28143 |
Available files
Filename: Papanastasiou et al IEEE TRPMS.pdf