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Crosstalk between the mTOR and DNA Damage Response Pathways in Fission Yeast

Alao, John-Patrick and Legon, Luc and Rallis, Charalampos (2021) 'Crosstalk between the mTOR and DNA Damage Response Pathways in Fission Yeast.' Cells, 10 (2). ISSN 2073-4409

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Abstract

Cells have developed response systems to constantly monitor environmental changes and accordingly adjust growth, differentiation, and cellular stress programs. The evolutionarily conserved, nutrient-responsive, mechanistic target of rapamycin signaling (mTOR) pathway coordinates basic anabolic and catabolic cellular processes such as gene transcription, protein translation, autophagy, and metabolism, and is directly implicated in cellular and organismal aging as well as age-related diseases. mTOR mediates these processes in response to a broad range of inputs such as oxygen, amino acids, hormones, and energy levels, as well as stresses, including DNA damage. Here, we briefly summarize data relating to the interplays of the mTOR pathway with DNA damage response pathways in fission yeast, a favorite model in cell biology, and how these interactions shape cell decisions, growth, and cell-cycle progression. We, especially, comment on the roles of caffeine-mediated DNA-damage override. Understanding the biology of nutrient response, DNA damage and related pharmacological treatments can lead to the design of interventions towards improved cellular and organismal fitness, health, and survival.

Item Type: Article
Uncontrolled Keywords: TORC1; TORC2; nutrients; caffeine; rapamycin; Rad3
Divisions: Faculty of Science and Health > Life Sciences, School of
Depositing User: Elements
Date Deposited: 08 Feb 2021 14:00
Last Modified: 08 Feb 2021 14:15
URI: http://repository.essex.ac.uk/id/eprint/29722

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