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Electrophysiological mechanisms underlying T-wave alternans and their role in arrhythmogenesis

You, Tingting and Luo, Cunjin and Zhang, Kevin and Zhang, Henggui (2021) 'Electrophysiological mechanisms underlying T-wave alternans and their role in arrhythmogenesis.' Frontiers in Physiology, 12. ISSN 1664-042X

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Abstract

T-wave alternans (TWA) reflects every-other-beat alterations in the morphology of the electrocardiogram ST segment or T wave in the setting of a constant heart rate, hence, in the absence of heart rate variability. It is believed to be associated with the dispersion of repolarization and has been used as a non-invasive marker for predicting the risk of malignant cardiac arrhythmias and sudden cardiac death as numerous studies have shown. This review aims to provide up-to-date review on both experimental and simulation studies in elucidating possible mechanisms underlying the genesis of TWA at the cellular level, as well as the genesis of spatially concordant/discordant alternans at the tissue level, and their transition to cardiac arrhythmia. Recent progress and future perspectives in antiarrhythmic therapies associated with TWA are also discussed.

Item Type: Article
Uncontrolled Keywords: T-wave alternans, sudden cardiac death, spatial discordant alternans, arrhythmia, simulation
Divisions: Faculty of Science and Health > Computer Science and Electronic Engineering, School of
Depositing User: Elements
Date Deposited: 04 Mar 2021 09:09
Last Modified: 04 Mar 2021 09:09
URI: http://repository.essex.ac.uk/id/eprint/29877

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