Medvedeva, Angela and Saw, Rebecca and Silvestri, Carla and Sirota, Miroslav and Fuggetta, Giorgio and Galli, Giulia (2021) Offset-related brain activity in the left ventrolateral prefrontal cortex promotes long-term memory formation of verbal events. Brain Stimulation, 14 (3). pp. 564-570. DOI https://doi.org/10.1016/j.brs.2021.03.002
Medvedeva, Angela and Saw, Rebecca and Silvestri, Carla and Sirota, Miroslav and Fuggetta, Giorgio and Galli, Giulia (2021) Offset-related brain activity in the left ventrolateral prefrontal cortex promotes long-term memory formation of verbal events. Brain Stimulation, 14 (3). pp. 564-570. DOI https://doi.org/10.1016/j.brs.2021.03.002
Medvedeva, Angela and Saw, Rebecca and Silvestri, Carla and Sirota, Miroslav and Fuggetta, Giorgio and Galli, Giulia (2021) Offset-related brain activity in the left ventrolateral prefrontal cortex promotes long-term memory formation of verbal events. Brain Stimulation, 14 (3). pp. 564-570. DOI https://doi.org/10.1016/j.brs.2021.03.002
Abstract
Background: Recent evidence suggests that brain activity following the offset of a stimulus during encoding contributes to long-term memory formation, however the exact mechanisms underlying offset-related encoding are still unclear. Objectives: Here, in three transcranial magnetic stimulation studies (rTMS) we investigated offset-related activity in the left ventrolateral prefrontal cortex (VLPFC). rTMS was administered at different points in time around stimulus offset while participants encoded visually-presented words or pairs of words. The analyses focused on the effects of the stimulation on subsequent memory performance. Results: rTMS administered at the offset of the stimuli, but not during online encoding, disrupted subsequent memory performance. In Experiment 1 we found that rTMS specifically disrupted encoding mechanisms initiated by the offset of the stimuli rather than general, post-stimulus processes. Experiment 2 showed that this effect was not dependent upon rTMS-induced somatosensory effects. In a third rTMS experiment we further demonstrated a robust decline in associative memory performance when the stimulation was delivered at the offset of the word pairs, suggesting that offset-related encoding may contribute to the binding of information into an episodic memory trace. Conclusions: The offset of the stimulus may represent an event boundary that promotes the reinstatement of the previously experienced event and episodic binding.
Item Type: | Article |
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Uncontrolled Keywords: | Ventrolateral prefrontal cortex; Long-term memory; rTMS; Episodic memory formation; Verbal memory |
Divisions: | Faculty of Science and Health Faculty of Science and Health > Psychology, Department of |
SWORD Depositor: | Unnamed user with email elements@essex.ac.uk |
Depositing User: | Unnamed user with email elements@essex.ac.uk |
Date Deposited: | 10 Mar 2021 16:52 |
Last Modified: | 07 Aug 2024 20:44 |
URI: | http://repository.essex.ac.uk/id/eprint/30022 |
Available files
Filename: PIIS1935861X21000498.pdf
Licence: Creative Commons: Attribution-Noncommercial-No Derivative Works 3.0