Ameen-Ali, Kamar E and Sivakumaran, Magali H and Eacott, Madeline and O’Connor, Akira R and Ainge, James A and Easton, Alexander (2021) Perirhinal cortex and the recognition of relative familiarity. Neurobiology of Learning and Memory, 182. p. 107439. DOI https://doi.org/10.1016/j.nlm.2021.107439
Ameen-Ali, Kamar E and Sivakumaran, Magali H and Eacott, Madeline and O’Connor, Akira R and Ainge, James A and Easton, Alexander (2021) Perirhinal cortex and the recognition of relative familiarity. Neurobiology of Learning and Memory, 182. p. 107439. DOI https://doi.org/10.1016/j.nlm.2021.107439
Ameen-Ali, Kamar E and Sivakumaran, Magali H and Eacott, Madeline and O’Connor, Akira R and Ainge, James A and Easton, Alexander (2021) Perirhinal cortex and the recognition of relative familiarity. Neurobiology of Learning and Memory, 182. p. 107439. DOI https://doi.org/10.1016/j.nlm.2021.107439
Abstract
Spontaneous object recognition (SOR) is a widely used task of recognition memory in rodents which relies on their propensity to explore novel (or relatively novel) objects. Network models typically define perirhinal cortex as a region required for recognition of previously seen objects largely based on findings that lesions or inactivations of this area produce SOR deficits. However, relatively little is understood about the relationship between the activity of cells in the perirhinal cortex that signal novelty and familiarity and the behavioural responses of animals in the SOR task. Previous studies have used objects that are either highly familiar or absolutely novel, but everyday memory is for objects that sit on a spectrum of familiarity which includes objects that have been seen only a few times, or objects that are similar to objects which have been previously experienced. We present two studies that explore cellular activity (through c-fos imaging) within perirhinal cortex of rats performing SOR where the familiarity of objects has been manipulated. Despite robust recognition memory performance, we show no significant changes in perirhinal activity related to the level of familiarity of the objects. Reasons for this lack of familiarity-related modulation in perirhinal cortex activity are discussed. The current findings support emerging evidence that perirhinal responses to novelty are complex and that task demands are critical to the involvement of perirhinal cortex in the control of object recognition memory.
Item Type: | Article |
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Uncontrolled Keywords: | Recognition memory; Rat; cfos; Spontaneous object recognition |
Divisions: | Faculty of Science and Health Faculty of Science and Health > Psychology, Department of |
SWORD Depositor: | Unnamed user with email elements@essex.ac.uk |
Depositing User: | Unnamed user with email elements@essex.ac.uk |
Date Deposited: | 12 Apr 2021 11:53 |
Last Modified: | 07 Aug 2024 18:29 |
URI: | http://repository.essex.ac.uk/id/eprint/30178 |
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