Ahluwalia, Tarunveer S and Prins, Bram P and Kumari, Meena and et al (2021) Genome-wide association study of circulating interleukin 6 levels identifies novel loci. Human Molecular Genetics, 30 (5). pp. 393-409. DOI https://doi.org/10.1093/hmg/ddab023
Ahluwalia, Tarunveer S and Prins, Bram P and Kumari, Meena and et al (2021) Genome-wide association study of circulating interleukin 6 levels identifies novel loci. Human Molecular Genetics, 30 (5). pp. 393-409. DOI https://doi.org/10.1093/hmg/ddab023
Ahluwalia, Tarunveer S and Prins, Bram P and Kumari, Meena and et al (2021) Genome-wide association study of circulating interleukin 6 levels identifies novel loci. Human Molecular Genetics, 30 (5). pp. 393-409. DOI https://doi.org/10.1093/hmg/ddab023
Abstract
Interleukin 6 (IL-6) is a multifunctional cytokine with both pro- and anti-inflammatory properties with a heritability estimate of up to 61%. The circulating levels of IL-6 in blood have been associated with an increased risk of complex disease pathogenesis. We conducted a two-staged, discovery and replication meta genome-wide association study (GWAS) of circulating serum IL-6 levels comprising up to 67 428 (ndiscovery = 52 654 and nreplication = 14 774) individuals of European ancestry. The inverse variance fixed effects based discovery meta-analysis, followed by replication led to the identification of two independent loci, IL1F10/IL1RN rs6734238 on chromosome (Chr) 2q14, (Pcombined = 1.8 × 10-11), HLA-DRB1/DRB5 rs660895 on Chr6p21 (Pcombined = 1.5 × 10-10) in the combined meta-analyses of all samples. We also replicated the IL6R rs4537545 locus on Chr1q21 (Pcombined = 1.2 × 10-122). Our study identifies novel loci for circulating IL-6 levels uncovering new immunological and inflammatory pathways that may influence IL-6 pathobiology.
Item Type: | Article |
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Uncontrolled Keywords: | CHARGE Inflammation Working Group |
Divisions: | Faculty of Social Sciences Faculty of Social Sciences > Institute for Social and Economic Research |
SWORD Depositor: | Unnamed user with email elements@essex.ac.uk |
Depositing User: | Unnamed user with email elements@essex.ac.uk |
Date Deposited: | 14 Oct 2021 09:19 |
Last Modified: | 07 Aug 2024 18:29 |
URI: | http://repository.essex.ac.uk/id/eprint/31020 |
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