Mahmoud, Osama and Granell, Raquel and Tilling, Kate and Minelli, Cosetta and Garcia-Aymerich, Judith and Holloway, John W and Custovic, Adnan and Jarvis, Deborah and Sterne, Jonathan and Henderson, John (2018) Association of Height Growth in Puberty with Lung Function. A Longitudinal Study. American Journal of Respiratory and Critical Care Medicine, 198 (12). pp. 1539-1548. DOI https://doi.org/10.1164/rccm.201802-0274oc
Mahmoud, Osama and Granell, Raquel and Tilling, Kate and Minelli, Cosetta and Garcia-Aymerich, Judith and Holloway, John W and Custovic, Adnan and Jarvis, Deborah and Sterne, Jonathan and Henderson, John (2018) Association of Height Growth in Puberty with Lung Function. A Longitudinal Study. American Journal of Respiratory and Critical Care Medicine, 198 (12). pp. 1539-1548. DOI https://doi.org/10.1164/rccm.201802-0274oc
Mahmoud, Osama and Granell, Raquel and Tilling, Kate and Minelli, Cosetta and Garcia-Aymerich, Judith and Holloway, John W and Custovic, Adnan and Jarvis, Deborah and Sterne, Jonathan and Henderson, John (2018) Association of Height Growth in Puberty with Lung Function. A Longitudinal Study. American Journal of Respiratory and Critical Care Medicine, 198 (12). pp. 1539-1548. DOI https://doi.org/10.1164/rccm.201802-0274oc
Abstract
<b>Rationale:</b> Puberty may influence lung function, but the precise role of pubertal height growth in lung development is unclear.<b>Objectives:</b> To examine associations of timing of puberty and peak velocity of pubertal height growth with lung function in adolescence and early adulthood.<b>Methods:</b> Longitudinal analyses of repeat height measurements from age 5 to 20 years for a British birth cohort with 4,772 males and 4,849 females were conducted to characterize height growth trajectories and to derive pubertal age and peak height velocity using the validated SITAR (SuperImposition by Translation and Rotation) model. Association of these estimates with prebronchodilator and post-bronchodilator spirometry measures: FEV<sub>1</sub>; FVC; FEV<sub>1</sub>/FVC; FEF<sub>25-75%</sub> at age 15 and 24 years were investigated using multivariable regression models adjusted for lung function at age 8 years, height and age at time of outcome measurements, and potential confounders.<b>Measurements and Main Results:</b> Later pubertal age and greater peak velocity were associated with higher FEV<sub>1</sub> and FVC at 24 years in both sexes. A 1-year increase in pubertal age was associated with a 263-ml higher FVC (95% confidence interval [CI], 167-360 ml) for males (<i>n</i> = 567) and 100-ml (95% CI, 50-150 ml) higher FVC for females (<i>n</i> = 990). A 1-cm/yr increase in peak velocity was associated with 145-ml (95% CI, 56-234 ml) and 50-ml (95% CI, 2-99 ml) increases in FVC for males and females, respectively. No associations were found with FEV<sub>1</sub>/FVC.<b>Conclusions:</b> Later onset and greater peak velocity of height growth in puberty are associated with increased FEV<sub>1</sub> and FVC in young adults but there was no evidence of dysanapsis of pubertal lung growth.
Item Type: | Article |
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Uncontrolled Keywords: | Adolescent; Body Height; Child; Child, Preschool; Female; Growth; Humans; Longitudinal Studies; Lung; Male; Puberty; Respiratory Function Tests; Young Adult |
Divisions: | Faculty of Science and Health Faculty of Science and Health > Mathematics, Statistics and Actuarial Science, School of |
SWORD Depositor: | Unnamed user with email elements@essex.ac.uk |
Depositing User: | Unnamed user with email elements@essex.ac.uk |
Date Deposited: | 03 Feb 2023 16:37 |
Last Modified: | 30 Oct 2024 16:18 |
URI: | http://repository.essex.ac.uk/id/eprint/32202 |
Available files
Filename: 2018_Mahmoud_et_al-Association of ht growth in puberty_Original.pdf