Yiend, Jenny and Lam, Charlene LM and Schmidt, Nora and Crane, Bryony and Heslin, Margaret and Kabir, Thomas and McGuire, Philip and Meek, Christopher and Mouchlianitis, Elias and Peters, Emmanuelle and Stahl, Daniel and Trotta, Antonella and Shergill, Sukhwinder (2023) Cognitive bias modification for paranoia (CBM-pa): a randomised controlled feasibility study in patients with distressing paranoid beliefs. Psychological Medicine, 53 (10). pp. 4614-4626. DOI https://doi.org/10.1017/s0033291722001520
Yiend, Jenny and Lam, Charlene LM and Schmidt, Nora and Crane, Bryony and Heslin, Margaret and Kabir, Thomas and McGuire, Philip and Meek, Christopher and Mouchlianitis, Elias and Peters, Emmanuelle and Stahl, Daniel and Trotta, Antonella and Shergill, Sukhwinder (2023) Cognitive bias modification for paranoia (CBM-pa): a randomised controlled feasibility study in patients with distressing paranoid beliefs. Psychological Medicine, 53 (10). pp. 4614-4626. DOI https://doi.org/10.1017/s0033291722001520
Yiend, Jenny and Lam, Charlene LM and Schmidt, Nora and Crane, Bryony and Heslin, Margaret and Kabir, Thomas and McGuire, Philip and Meek, Christopher and Mouchlianitis, Elias and Peters, Emmanuelle and Stahl, Daniel and Trotta, Antonella and Shergill, Sukhwinder (2023) Cognitive bias modification for paranoia (CBM-pa): a randomised controlled feasibility study in patients with distressing paranoid beliefs. Psychological Medicine, 53 (10). pp. 4614-4626. DOI https://doi.org/10.1017/s0033291722001520
Abstract
Background Cognitive Bias Modification for paranoia (CBM-pa) is a novel, theory-driven psychological intervention targeting the biased interpretation of emotional ambiguity associated with paranoia. Study objectives were (i) test the intervention's feasibility, (ii) provide effect size estimates, (iii) assess dose–response and (iv) select primary outcomes for future trials. Methods In a double-blind randomised controlled trial, sixty-three outpatients with clinically significant paranoia were randomised to either CBM-pa or an active control (text reading) between April 2016 and September 2017. Patients received one 40 min session per week for 6 weeks. Assessments were given at baseline, after each interim session, post-treatment, and at 1- and 3-months post-treatment. Results A total of 122 patients were screened and 63 were randomised. The recruitment rate was 51.2%, with few dropouts (four out of 63) and follow-up rates were 90.5% (1-month) and 93.7% (3-months). Each session took 30–40 min to complete. There was no statistical evidence of harmful effects of the intervention. Preliminary data were consistent with efficacy of CBM-pa over text-reading control: patients randomised to the intervention, compared to control patients, reported reduced interpretation bias (d = −0.48 to −0.76), improved symptoms of paranoia (d = −0.19 to −0.38), and lower depressed and anxious mood (d = −0.03 to −0.29). The intervention effect was evident after the third session. Conclusions CBM-pa is feasible for patients with paranoia. A fully powered randomised control trial is warranted.
Item Type: | Article |
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Uncontrolled Keywords: | Anxiety; Bias; Cognition; Double-Blind Method; Feasibility Studies; Humans; Paranoid Disorders |
Divisions: | Faculty of Science and Health Faculty of Science and Health > Health and Social Care, School of |
SWORD Depositor: | Unnamed user with email elements@essex.ac.uk |
Depositing User: | Unnamed user with email elements@essex.ac.uk |
Date Deposited: | 03 Oct 2023 12:59 |
Last Modified: | 16 May 2024 21:22 |
URI: | http://repository.essex.ac.uk/id/eprint/33037 |
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Licence: Creative Commons: Attribution 4.0