McPherson, Susan and Senra, Hugo (2022) Psychological treatments for persistent depression: A systematic review and meta-analysis of quality of life and functioning outcomes. Psychotherapy, 59 (3). pp. 447-459. DOI https://doi.org/10.1037/pst0000448
McPherson, Susan and Senra, Hugo (2022) Psychological treatments for persistent depression: A systematic review and meta-analysis of quality of life and functioning outcomes. Psychotherapy, 59 (3). pp. 447-459. DOI https://doi.org/10.1037/pst0000448
McPherson, Susan and Senra, Hugo (2022) Psychological treatments for persistent depression: A systematic review and meta-analysis of quality of life and functioning outcomes. Psychotherapy, 59 (3). pp. 447-459. DOI https://doi.org/10.1037/pst0000448
Abstract
To date it is unclear whether psychological therapies have potential to improve quality of life and functioning in patients with persistent depression. This meta-analysis examines the effect of psychological therapies for improving quality of life and functioning in patients with persistent forms of depression. Data sources include Medline and Meta-Analytic Psychotherapy Database (METAPSY), searched 07/2021. Eligible studies were randomized controlled trials where participants had major depressive disorder on entry and met criteria for a persistent form of depression, for example, chronic, treatment resistant or recurrent depression. Standardized mean differences (Hedge’s g) were calculated in random-effects meta-analyses. Fourteen studies met inclusion criteria (N = 1898). Psychological interventions were associated with improvements in patients’ quality of life at the end of treatment: pooled g = 0.24 (95% confidence intervals [CIs] 0.13–0.34); low to moderate levels of heterogeneity (I² = 0% [95% CI 0%–41.2%]). Quality of life at follow-up: pooled g = 0.21 (95% CI 0.01–0.32); low to high levels of heterogeneity considering the wide CI for I² (I² = 10.36% [95% CI 0%–77.5%]). The psychological interventions were associated with improvements in patients’ functioning at end of treatment: pooled g = 0.34 (95% CI 0.21–0.48); low to high levels of heterogeneity considering the wide CI for I² (I² = 0% [95% CI 0%–81.7%]). Functioning at follow-up resulted in: pooled g = 0.33 (95% CI 0.15–0.50); low to high levels of heterogeneity considering the wide CI for I² (I² = 0% [95% CI 0%–86.2%]). This meta-analysis highlights the potential benefits of psychological therapies for improving quality of life and functioning in patients with persistent depression, with strongest long-term effects for mindfulness-based cognitive therapy, interpersonal therapy in combination with antidepression medication, and long-term psychoanalytic psychotherapy.
Item Type: | Article |
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Uncontrolled Keywords: | Cognitive Behavioral Therapy; Depression; Depressive Disorder, Major; Humans; Mindfulness; Psychotherapy; Quality of Life; Randomized Controlled Trials as Topic |
Divisions: | Faculty of Science and Health Faculty of Science and Health > Health and Social Care, School of |
SWORD Depositor: | Unnamed user with email elements@essex.ac.uk |
Depositing User: | Unnamed user with email elements@essex.ac.uk |
Date Deposited: | 08 Nov 2022 13:28 |
Last Modified: | 07 Aug 2024 19:35 |
URI: | http://repository.essex.ac.uk/id/eprint/33080 |
Available files
Filename: McPherson_senra_Psychotherapy_2022_accepted.pdf