Gundersen, Rebekah Anamarie and Chu, Tianyuan and Abolfathi, Kiana and Gokcen Dogan, Serap and Blair, Phoebe Elizabeth and Nago, Nyasha and Hamblin, Michael and Brooke, Greg Nicholas and Zwacka, Ralf Michael and Kafash Hoshiar, Ali and Mohr, Andrea (2023) Generation of magnetic biohybrid microrobots based on MSC.sTRAIL for targeted stem cell delivery and treatment of cancer. Cancer Nanotechnology, 14 (1). 54-. DOI https://doi.org/10.1186/s12645-023-00203-9
Gundersen, Rebekah Anamarie and Chu, Tianyuan and Abolfathi, Kiana and Gokcen Dogan, Serap and Blair, Phoebe Elizabeth and Nago, Nyasha and Hamblin, Michael and Brooke, Greg Nicholas and Zwacka, Ralf Michael and Kafash Hoshiar, Ali and Mohr, Andrea (2023) Generation of magnetic biohybrid microrobots based on MSC.sTRAIL for targeted stem cell delivery and treatment of cancer. Cancer Nanotechnology, 14 (1). 54-. DOI https://doi.org/10.1186/s12645-023-00203-9
Gundersen, Rebekah Anamarie and Chu, Tianyuan and Abolfathi, Kiana and Gokcen Dogan, Serap and Blair, Phoebe Elizabeth and Nago, Nyasha and Hamblin, Michael and Brooke, Greg Nicholas and Zwacka, Ralf Michael and Kafash Hoshiar, Ali and Mohr, Andrea (2023) Generation of magnetic biohybrid microrobots based on MSC.sTRAIL for targeted stem cell delivery and treatment of cancer. Cancer Nanotechnology, 14 (1). 54-. DOI https://doi.org/10.1186/s12645-023-00203-9
Abstract
Background Combining the power of magnetic guidance and the biological activities of stem cells transformed into biohybrid microrobots holds great promise for the treatment of several diseases including cancer. Results We found that human MSCs can be readily loaded with magnetic particles and that the resulting biohybrid microrobots could be guided by a rotating magnetic field. Rotating magnetic fields have the potential to be applied in the human setting and steer therapeutic stem cells to the desired sites of action in the body. We could demonstrate that the required loading of magnetic particles into stem cells is compatible with their biological activities. We examined this issue with a particular focus on the expression and functionality of therapeutic genes inside of human MSC-based biohybrid microrobots. The loading with magnetic particles did not cause a loss of viability or apoptosis in the human MSCs nor did it impact on the therapeutic gene expression from the cells. Furthermore, the therapeutic effect of the gene products was not affected, and the cells also did not lose their migration potential. Conclusion These results demonstrate that the fabrication of guidable MSC-based biohybrid microrobots is compatible with their biological and therapeutic functions. Thus, MSC-based biohybrid microrobots represent a novel way of delivering gene therapies to tumours as well as in the context of other diseases.
Item Type: | Article |
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Uncontrolled Keywords: | Biohybrid microrobots; Mesenchymal stromal cells; sTRAIL; sPD1HAC; Rotating magnetic field; Mesenchymal stem cells; Cancer |
Subjects: | Z Bibliography. Library Science. Information Resources > ZZ OA Fund (articles) |
Divisions: | Faculty of Science and Health Faculty of Science and Health > Life Sciences, School of Faculty of Science and Health > Computer Science and Electronic Engineering, School of |
SWORD Depositor: | Unnamed user with email elements@essex.ac.uk |
Depositing User: | Unnamed user with email elements@essex.ac.uk |
Date Deposited: | 20 Jul 2023 12:33 |
Last Modified: | 07 Aug 2024 20:18 |
URI: | http://repository.essex.ac.uk/id/eprint/35819 |
Available files
Filename: s12645-023-00203-9.pdf
Licence: Creative Commons: Attribution 4.0