Reeder, Brandon J (2023) Insights into the function of cytoglobin. Biochemical Society Transactions, 51 (5). pp. 1907-1919. DOI https://doi.org/10.1042/bst20230081
Reeder, Brandon J (2023) Insights into the function of cytoglobin. Biochemical Society Transactions, 51 (5). pp. 1907-1919. DOI https://doi.org/10.1042/bst20230081
Reeder, Brandon J (2023) Insights into the function of cytoglobin. Biochemical Society Transactions, 51 (5). pp. 1907-1919. DOI https://doi.org/10.1042/bst20230081
Abstract
Since its discovery in 2001, the function of cytoglobin has remained elusive. Through extensive in vitro and in vivo research, a range of potential physiological and pathological mechanisms has emerged for this multifunctional member of the hemoglobin family. Currently, over 200 research publications have examined different aspects of cytoglobin structure, redox chemistry and potential roles in cell signalling pathways. This research is wide ranging, but common themes have emerged throughout the research. This review examines the current structural, biochemical and in vivo knowledge of cytoglobin published over the past two decades. Radical scavenging, nitric oxide homeostasis, lipid binding and oxidation and the role of an intramolecular disulfide bond on the redox chemistry are examined, together with aspects and roles for Cygb in cancer progression and liver fibrosis.
Item Type: | Article |
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Uncontrolled Keywords: | cytoglobin, disulphide bonds, protein structure, redox chemistry |
Divisions: | Faculty of Science and Health Faculty of Science and Health > Life Sciences, School of |
SWORD Depositor: | Unnamed user with email elements@essex.ac.uk |
Depositing User: | Unnamed user with email elements@essex.ac.uk |
Date Deposited: | 26 Sep 2023 15:49 |
Last Modified: | 16 May 2024 22:02 |
URI: | http://repository.essex.ac.uk/id/eprint/36421 |
Available files
Filename: 2023 BST.pdf
Licence: Creative Commons: Attribution 4.0