Rodriguez Macia, Patricia and Depala, Anjali and Lachmann, Manon T and Morra, Simone and Birrell, James A (2025) Terminal hydride formation in [FeFe] hydrogenase: understanding the role of the dithiolate bridgehead. Chemical Communications, 61 (33). pp. 6178-6181. DOI https://doi.org/10.1039/D5CC00860C
Rodriguez Macia, Patricia and Depala, Anjali and Lachmann, Manon T and Morra, Simone and Birrell, James A (2025) Terminal hydride formation in [FeFe] hydrogenase: understanding the role of the dithiolate bridgehead. Chemical Communications, 61 (33). pp. 6178-6181. DOI https://doi.org/10.1039/D5CC00860C
Rodriguez Macia, Patricia and Depala, Anjali and Lachmann, Manon T and Morra, Simone and Birrell, James A (2025) Terminal hydride formation in [FeFe] hydrogenase: understanding the role of the dithiolate bridgehead. Chemical Communications, 61 (33). pp. 6178-6181. DOI https://doi.org/10.1039/D5CC00860C
Abstract
[FeFe]-hydrogenases are highly-active hydrogen-conversion biocatalysts using Earth-abundant metals in their active-site. Understanding their mechanism may enable design of catalysts for renewable energy storage. Here, observation of the crucial Fe-hydride-containing (Hhyd) intermediate in a PDT-variant of [FeFe]-hydrogenase reveals deeper insight into the role of the dithiolate bridgehead in the catalytic mechanism.
| Item Type: | Article |
|---|---|
| Divisions: | Faculty of Science and Health Faculty of Science and Health > Life Sciences, School of |
| SWORD Depositor: | Unnamed user with email elements@essex.ac.uk |
| Depositing User: | Unnamed user with email elements@essex.ac.uk |
| Date Deposited: | 24 Jun 2026 09:52 |
| Last Modified: | 24 Jun 2026 09:52 |
| URI: | http://repository.essex.ac.uk/id/eprint/40573 |
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Filename: Terminal hydride formation in [FeFe] hydrogenase understanding the role of the dithiolate bridgehead.pdf
Licence: Creative Commons: Attribution 4.0