KhayyamNet: A Parallel Multiscale Feature Fusion Framework for Accurate Diagnosis of Multiple Sclerosis and Myelitis

Multiple Sclerosis (MS) and Myelitis are serious inflammatory spinal cord disorders with overlapping clinical symptoms and radiological characteristics, making accurate differentiation challenging yet clinically essential. Early and precise diagnosis is critical for guiding treatment strategies and improving patient outcomes. In this study, we propose KhayyamNet, a novel hybrid deep learning architecture designed to fuse complementary local and global representations for the accurate diagnosis of MS and Myelitis using spinal MRI. To improve robustness and generalization capability, a comprehensive preprocessing strategy including data augmentation and intensity normalization is also applied to reduce noise and address data variability. The proposed architecture combines three complementary deep learning models for feature extraction composed of Xception for high-level semantic features, Convolutional Neural Networks (CNNs) for fine-grained local patterns, and Vision Transformers (ViTs) for global contextual representations via attention mechanisms. Extracted features are then fused and refined using the Minimum Redundancy Maximum Relevance (MRMR) algorithm to eliminate redundancy and retain the most informative signals. Finally, a Random Forest (RF) classifier utilizes the optimized feature set to achieve accurate and robust differentiation between MS, Myelitis, and control spinal MRIs. Experimental results demonstrate that KhayyamNet outperforms existing methods by achieving an average classification accuracy of 98.15±0.80%. This framework demonstrates promising performance for the automated analysis of spinal MRIs and shows potential to assist in the differentiation of MS and Myelitis. While these findings highlight the potential of KhayyamNet for automated MRI interpretation, its evaluation is limited to a single-center dataset, and further validation on external multi-center data is required.