Differential responses of adiposity, inflammation and autonomic function to aerobic versus resistance training in older adults

Background: Increased body fat, autonomic dysfunction and low-grade chronic inflammation are interrelated risk factors implicated in the etiology of several chronic conditions normally presented by older adults. Objective: This study aims to assess the effectiveness of different training protocols on reducing body fat, improving autonomic function, and decreasing low-grade systemic inflammation in community-dwelling elderly adults. Methods: Fifty participants (11 men, 68. ±. 5.5. years) were randomly allocated into resistance or aerobic training or control groups. Evaluations were done at baseline and following the 8-month intervention period on their body composition (assessed by DXA), inflammatory biomarkers (high-sensitivity C-reactive protein [hs-CRP], tumor necrosis-alpha [TNF-. α], interferon-gamma [IFN-γ], interleukins-6 and -10 [IL-6, IL-10]), lipoproteic profile, fasting glycemia, blood pressure, heart rate variability (HRV; frequency and time domains) and aerobic fitness (assessed by six-minute walk distance [6MWD]). A paired t-test was used to detect changes (%δ. =. [(post-test score. -. pretest score). /. pre-test score]. ×. 100) within groups, while between-group differences were analyzed using the one-way ANOVA or General Linear Models. Results: A significant change (δ%) both in total (-. 5.4. ±. 6.3% and -. 3.3. ±. 2.9%, respectively) and central body fat (8.9. ±. 11.3% and -. 4.8. ±. 4.5%) was observed in resistance and aerobic training groups, respectively; along with a change in resting systolic and diastolic blood pressures (-. 9.2. ±. 9.8% and -. 8.5. ±. 9.6%), heart rate (-. 4.6. ±. 6.5%), hs-CRP (-. 18.6. ±. 60.6%), and 6MWD (9.5. ±. 6.9%) in response to aerobic training. Conclusions: The present findings provide further evidence for the benefits of aerobic and resistance training on reducing body fat. Aerobic training was demonstrated to reduce hs-CRP and blood pressure in community-dwelling elderly participants with no serious medical conditions. © 2013 Elsevier Inc.