Fritz, Eberhard and Friedl, Anna A and Zwacka, Ralf M and Eckardt-Schupp, Friederike and Meyn, M Stephen (2000) The Yeast<i>TEL1</i>Gene Partially Substitutes for Human<i>ATM</i>in Suppressing Hyperrecombination, Radiation-Induced Apoptosis and Telomere Shortening in A-T Cells. Molecular Biology of the Cell, 11 (8). pp. 2605-2616. DOI https://doi.org/10.1091/mbc.11.8.2605
Fritz, Eberhard and Friedl, Anna A and Zwacka, Ralf M and Eckardt-Schupp, Friederike and Meyn, M Stephen (2000) The Yeast<i>TEL1</i>Gene Partially Substitutes for Human<i>ATM</i>in Suppressing Hyperrecombination, Radiation-Induced Apoptosis and Telomere Shortening in A-T Cells. Molecular Biology of the Cell, 11 (8). pp. 2605-2616. DOI https://doi.org/10.1091/mbc.11.8.2605
Fritz, Eberhard and Friedl, Anna A and Zwacka, Ralf M and Eckardt-Schupp, Friederike and Meyn, M Stephen (2000) The Yeast<i>TEL1</i>Gene Partially Substitutes for Human<i>ATM</i>in Suppressing Hyperrecombination, Radiation-Induced Apoptosis and Telomere Shortening in A-T Cells. Molecular Biology of the Cell, 11 (8). pp. 2605-2616. DOI https://doi.org/10.1091/mbc.11.8.2605
Abstract
<jats:p>Homozygous mutations in the human ATM gene lead to a pleiotropic clinical phenotype of ataxia-telangiectasia (A-T) patients and correlating cellular deficiencies in cells derived from A-T donors. Saccharomyces cerevisiae tel1 mutants lacking Tel1p, which is the closest sequence homologue to the ATM protein, share some of the cellular defects with A-T. Through genetic complementation of A-T cells with the yeast TEL1 gene, we provide evidence that Tel1p can partially compensate for ATM in suppressing hyperrecombination, radiation-induced apoptosis, and telomere shortening. Complementation appears to be independent of p53 activation. The data provided suggest that TEL1 is a functional homologue of human ATM in yeast, and they help to elucidate different cellular and biochemical pathways in human cells regulated by the ATM protein.</jats:p>
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Cell Line, Transformed; Telomere; Fibroblasts; Humans; Saccharomyces cerevisiae; Intracellular Signaling Peptides and Proteins; Cell Cycle Proteins; DNA-Binding Proteins; Fungal Proteins; Saccharomyces cerevisiae Proteins; Tumor Suppressor Proteins; Genetic Complementation Test; Transfection; Apoptosis; Recombination, Genetic; Mutation; Gamma Rays; Tumor Suppressor Protein p53; Ataxia Telangiectasia Mutated Proteins; Protein Serine-Threonine Kinases |
| Subjects: | R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer) |
| Divisions: | Faculty of Science and Health Faculty of Science and Health > Life Sciences, School of |
| SWORD Depositor: | Unnamed user with email elements@essex.ac.uk |
| Depositing User: | Unnamed user with email elements@essex.ac.uk |
| Date Deposited: | 03 Jul 2017 09:08 |
| Last Modified: | 04 Dec 2024 06:40 |
| URI: | http://repository.essex.ac.uk/id/eprint/8340 |