Zwacka, RM and Reuter, A and Pfaff, E and Moll, J and Gorgas, K and Karasawa, M and Weiher, H (1994) The glomerulosclerosis gene Mpv17 encodes a peroxisomal protein producing reactive oxygen species. The EMBO Journal, 13 (21). pp. 5129-5134. DOI https://doi.org/10.1002/j.1460-2075.1994.tb06842.x
Zwacka, RM and Reuter, A and Pfaff, E and Moll, J and Gorgas, K and Karasawa, M and Weiher, H (1994) The glomerulosclerosis gene Mpv17 encodes a peroxisomal protein producing reactive oxygen species. The EMBO Journal, 13 (21). pp. 5129-5134. DOI https://doi.org/10.1002/j.1460-2075.1994.tb06842.x
Zwacka, RM and Reuter, A and Pfaff, E and Moll, J and Gorgas, K and Karasawa, M and Weiher, H (1994) The glomerulosclerosis gene Mpv17 encodes a peroxisomal protein producing reactive oxygen species. The EMBO Journal, 13 (21). pp. 5129-5134. DOI https://doi.org/10.1002/j.1460-2075.1994.tb06842.x
Abstract
The mutant mouse strain Mpv17 carries a retroviral insert in its genome which inactivates the Mpv17 gene. At a young age these mice develop glomerulosclerosis and nephrotic syndrome which resembles human disease. We show here that the Mpv17 gene product is highly conserved and encodes a peroxisomal protein. Loss of the Mpv17 protein does not impair peroxisome biogenesis but instead leads to a reduced ability to produce reactive oxygen species (ROS). In turn, overproduction of the Mpv17 gene in transfected cells results in dramatically enhanced levels of intracellular ROS indicating a direct involvement of Mpv17 in ROS production. These data reveal a role for the Mpv17 protein in peroxisomal reactive oxygen metabolism and establish a novel link between peroxisomal ROS production and glomerulosclerosis.
Item Type: | Article |
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Uncontrolled Keywords: | GLOMERULOSCLEROSIS MOUSE MODEL; PEROXISOMES; REACTIVE OXYGEN SPECIES |
Subjects: | R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer) |
Divisions: | Faculty of Science and Health Faculty of Science and Health > Life Sciences, School of |
SWORD Depositor: | Unnamed user with email elements@essex.ac.uk |
Depositing User: | Unnamed user with email elements@essex.ac.uk |
Date Deposited: | 04 Jul 2017 11:26 |
Last Modified: | 07 Aug 2024 20:07 |
URI: | http://repository.essex.ac.uk/id/eprint/8360 |