Boutaud, Olivier and Moore, Kevin P and Reeder, Brandon J and Harry, David and Howie, Alexander J and Wang, Shuhe and Carney, Clare K and Masterson, Tina S and Amin, Taneem and Wright, David W and Wilson, Michael T and Oates, John A and Roberts, L Jackson (2010) Acetaminophen inhibits hemoprotein-catalyzed lipid peroxidation and attenuates rhabdomyolysis-induced renal failure. Proceedings of the National Academy of Sciences, 107 (6). pp. 2699-2704. DOI https://doi.org/10.1073/pnas.0910174107
Boutaud, Olivier and Moore, Kevin P and Reeder, Brandon J and Harry, David and Howie, Alexander J and Wang, Shuhe and Carney, Clare K and Masterson, Tina S and Amin, Taneem and Wright, David W and Wilson, Michael T and Oates, John A and Roberts, L Jackson (2010) Acetaminophen inhibits hemoprotein-catalyzed lipid peroxidation and attenuates rhabdomyolysis-induced renal failure. Proceedings of the National Academy of Sciences, 107 (6). pp. 2699-2704. DOI https://doi.org/10.1073/pnas.0910174107
Boutaud, Olivier and Moore, Kevin P and Reeder, Brandon J and Harry, David and Howie, Alexander J and Wang, Shuhe and Carney, Clare K and Masterson, Tina S and Amin, Taneem and Wright, David W and Wilson, Michael T and Oates, John A and Roberts, L Jackson (2010) Acetaminophen inhibits hemoprotein-catalyzed lipid peroxidation and attenuates rhabdomyolysis-induced renal failure. Proceedings of the National Academy of Sciences, 107 (6). pp. 2699-2704. DOI https://doi.org/10.1073/pnas.0910174107
Abstract
<jats:p>Hemoproteins, hemoglobin and myoglobin, once released from cells can cause severe oxidative damage as a consequence of heme redox cycling between ferric and ferryl states that generates radical species that induce lipid peroxidation. We demonstrate in vitro that acetaminophen inhibits hemoprotein-induced lipid peroxidation by reducing ferryl heme to its ferric state and quenching globin radicals. Severe muscle injury (rhabdomyolysis) is accompanied by the release of myoglobin that becomes deposited in the kidney, causing renal injury. We previously showed in a rat model of rhabdomyolysis that redox cycling between ferric and ferryl myoglobin yields radical species that cause severe oxidative damage to the kidney. In this model, acetaminophen at therapeutic plasma concentrations significantly decreased oxidant injury in the kidney, improved renal function, and reduced renal damage. These findings also provide a hypothesis for potential therapeutic applications for acetaminophen in diseases involving hemoprotein-mediated oxidative injury.</jats:p>
Item Type: | Article |
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Uncontrolled Keywords: | isoprostanes; oxidative damage; hemoglobin; myoglobin |
Subjects: | Q Science > QH Natural history > QH301 Biology |
Divisions: | Faculty of Science and Health Faculty of Science and Health > Life Sciences, School of |
SWORD Depositor: | Unnamed user with email elements@essex.ac.uk |
Depositing User: | Unnamed user with email elements@essex.ac.uk |
Date Deposited: | 22 Sep 2011 15:40 |
Last Modified: | 07 Aug 2024 19:51 |
URI: | http://repository.essex.ac.uk/id/eprint/923 |