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Bioinformatics and molecular modelling approaches to GPCR oligomerization

Simpson, LM and Taddese, B and Wall, ID and Reynolds, CA (2010) 'Bioinformatics and molecular modelling approaches to GPCR oligomerization.' Current Opinion in Pharmacology, 10 (1). 30 - 37. ISSN 1471-4892

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The elusive nature of the structure and function of the G-protein coupled receptor (GPCR) dimer or oligomer has led to a variety of computational studies, most of which have been directed primarily towards understanding structure. Here we review some of the recent studies based on sequence analysis and docking experiments and the recent developments in GPCR structure that have underpinned dimerization studies. In addition, we review recent nanosecond molecular dynamics simulations and coarse-grained methods for investigating the dynamic consequences of dimerization. The strengths and weaknesses of these complementary methods are discussed. The consensus of a variety of studies is that several transmembrane helices are involved in the dimerization/oligomerization interface(s); computation has been particularly effective in elucidating the experiments that seem to indicate a key role for transmembrane helix 4. © 2009 Elsevier Ltd. All rights reserved.

Item Type: Article
Subjects: Q Science > Q Science (General)
Divisions: Faculty of Science and Health > Life Sciences, School of
Depositing User: Jim Jamieson
Date Deposited: 23 Sep 2011 09:17
Last Modified: 19 Aug 2019 18:15

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