Items where Author is "Miller, Laurence J"

Dong, Maoqing and Deganutti, Giuseppe and Piper, Sarah J and Liang, Yi-Lynn and Khoshouei, Maryam and Belousoff, Matthew J and Harikumar, Kaleeckal G and Reynolds, Christopher A and Glukhova, Alisa and Furness, Sebastian GB and Christopoulos, Arthur and Danev, Radostin and Wootten, Denise and Sexton, Patrick M and Miller, Laurence J (2020) Structure and dynamics of the active Gs-coupled human secretin receptor. Nature Communications, 11 (1). 4137-. DOI https://doi.org/10.1038/s41467-020-17791-4

Zhao, Peishen and Liang, Yi-Lynn and Belousoff, Matthew J and Deganutti, Giuseppe and Fletcher, Madeleine M and Willard, Francis S and Bell, Michael G and Christe, Michael E and Sloop, Kyle W and Inoue, Asuka and Truong, Tin T and Clydesdale, Lachlan and Furness, Sebastian GB and Christopoulos, Arthur and Wang, Ming-Wei and Miller, Laurence J and Reynolds, Christopher A and Danev, Radostin and Sexton, Patrick M and Wootten, Denise (2020) Activation of the GLP-1 receptor by a non-peptidic agonist. Nature, 577 (7790). pp. 432-436. DOI https://doi.org/10.1038/s41586-019-1902-z

dal Maso, Emma and Glukhova, Alisa and Zhu, Yue and Garcia-Nafria, Javier and Tate, Christopher G and Atanasio, Silvia and Reynolds, Christopher A and Ramírez-Aportela, Erney and Carazo, Jose-Maria and Hick, Caroline A and Furness, Sebastian GB and Hay, Debbie L and Liang, Yi-Lynn and Miller, Laurence J and Christopoulos, Arthur and Wang, Ming-Wei and Wootten, Denise and Sexton, Patrick M (2019) The Molecular Control of Calcitonin Receptor Signaling. ACS Pharmacology & Translational Science, 2 (1). pp. 31-51. DOI https://doi.org/10.1021/acsptsci.8b00056

Liang, Yi-Lynn and Khoshouei, Maryam and Deganutti, Giuseppe and Glukhova, Alisa and Koole, Cassandra and Peat, Thomas S and Radjainia, Mazdak and Plitzko, Jürgen M and Baumeister, Wolfgang and Miller, Laurence J and Hay, Deborah L and Christopoulos, Arthur and Reynolds, Christopher A and Wootten, Denise and Sexton, Patrick M (2018) Cryo-EM structure of the active, Gs-protein complexed, human CGRP receptor. Nature, 561 (7724). pp. 492-497. DOI https://doi.org/10.1038/s41586-018-0535-y

Wootten, Denise and Reynolds, Christopher A and Smith, Kevin J and Mobarec, Juan C and Furness, Sebastian GB and Miller, Laurence J and Christopoulos, Arthur and Sexton, Patrick M (2016) Key interactions by conserved polar amino acids located at the transmembrane helical boundaries in Class B GPCRs modulate activation, effector specificity and biased signalling in the glucagon-like peptide-1 receptor. Biochemical Pharmacology, 118. pp. 68-87. DOI https://doi.org/10.1016/j.bcp.2016.08.015

Wootten, Denise and Reynolds, Christopher A and Smith, Kevin J and Mobarec, Juan C and Koole, Cassandra and Savage, Emilia E and Pabreja, Kavita and Simms, John and Sridhar, Rohan and Furness, Sebastian GB and Liu, Mengjie and Thompson, Philip E and Miller, Laurence J and Christopoulos, Arthur and Sexton, Patrick M (2016) The Extracellular Surface of the GLP-1 Receptor Is a Molecular Trigger for Biased Agonism. Cell, 165 (7). pp. 1632-1643. DOI https://doi.org/10.1016/j.cell.2016.05.023

Wootten, Denise and Reynolds, Christopher A and Koole, Cassandra and Smith, Kevin J and Mobarec, Juan C and Simms, John and Quon, Tezz and Coudrat, Thomas and Furness, Sebastian GB and Miller, Laurence J and Christopoulos, Arthur and Sexton, Patrick M (2016) A Hydrogen-Bonded Polar Network in the Core of the Glucagon-Like Peptide-1 Receptor Is a Fulcrum for Biased Agonism: Lessons from Class B Crystal Structures. Molecular Pharmacology, 89 (3). pp. 335-347. DOI https://doi.org/10.1124/mol.115.101246