Items where Author is "Mobarec, Juan C"
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Koole, Cassandra and Reynolds, Christopher A and Mobarec, Juan C and Hick, Caroline and Sexton, Patrick M and Sakmar, Thomas P (2017) Genetically encoded photocross-linkers determine the biological binding site of exendin-4 peptide in the N-terminal domain of the intact human glucagon-like peptide-1 receptor (GLP-1R). Journal of Biological Chemistry, 292 (17). pp. 7131-7144. DOI https://doi.org/10.1074/jbc.M117.779496
Weaver, Richard E and Mobarec, Juan C and Wigglesworth, Mark J and Reynolds, Christopher A and Donnelly, Dan (2017) High affinity binding of the peptide agonist TIP-39 to the parathyroid hormone 2 (PTH 2 ) receptor requires the hydroxyl group of Tyr-318 on transmembrane helix 5. Biochemical Pharmacology, 127. pp. 71-81. DOI https://doi.org/10.1016/j.bcp.2016.12.013
Wootten, Denise and Reynolds, Christopher A and Smith, Kevin J and Mobarec, Juan C and Furness, Sebastian GB and Miller, Laurence J and Christopoulos, Arthur and Sexton, Patrick M (2016) Key interactions by conserved polar amino acids located at the transmembrane helical boundaries in Class B GPCRs modulate activation, effector specificity and biased signalling in the glucagon-like peptide-1 receptor. Biochemical Pharmacology, 118. pp. 68-87. DOI https://doi.org/10.1016/j.bcp.2016.08.015
Wootten, Denise and Reynolds, Christopher A and Smith, Kevin J and Mobarec, Juan C and Koole, Cassandra and Savage, Emilia E and Pabreja, Kavita and Simms, John and Sridhar, Rohan and Furness, Sebastian GB and Liu, Mengjie and Thompson, Philip E and Miller, Laurence J and Christopoulos, Arthur and Sexton, Patrick M (2016) The Extracellular Surface of the GLP-1 Receptor Is a Molecular Trigger for Biased Agonism. Cell, 165 (7). pp. 1632-1643. DOI https://doi.org/10.1016/j.cell.2016.05.023
Wootten, Denise and Reynolds, Christopher A and Koole, Cassandra and Smith, Kevin J and Mobarec, Juan C and Simms, John and Quon, Tezz and Coudrat, Thomas and Furness, Sebastian GB and Miller, Laurence J and Christopoulos, Arthur and Sexton, Patrick M (2016) A Hydrogen-Bonded Polar Network in the Core of the Glucagon-Like Peptide-1 Receptor Is a Fulcrum for Biased Agonism: Lessons from Class B Crystal Structures. Molecular Pharmacology, 89 (3). pp. 335-347. DOI https://doi.org/10.1124/mol.115.101246