Items where Author is "Simms, John"
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Simms, John and Uddin, Romez and Sakmar, Thomas P and Gingell, Joseph J and Garelja, Michael L and Hay, Debbie L and Brimble, Margaret A and Harris, Paul WR and Reynolds, Christopher A and Poyner, David R (2018) Photoaffinity cross-linking and unnatural amino acid mutagenesis reveal insights into calcitonin gene-related peptide binding to the calcitonin receptor-like receptor/receptor activity-modifying protein 1 (CLR/RAMP1) complex. Biochemistry, 57 (32). pp. 4915-4922. DOI https://doi.org/10.1021/acs.biochem.8b00502
Woolley, Michael J and Reynolds, Christopher A and Simms, John and Walker, Christopher S and Mobarec, Juan Carlos and Garelja, Michael L and Conner, Alex C and Poyner, David R and Hay, Debbie L (2017) Receptor activity-modifying protein dependent and independent activation mechanisms in the coupling of calcitonin gene-related peptide and adrenomedullin receptors to Gs. Biochemical Pharmacology, 142. pp. 96-110. DOI https://doi.org/10.1016/j.bcp.2017.07.005
Woolley, Michael J and Simms, John and Mobarec, Juan Carlos and Reynolds, Christopher A and Poyner, David R and Conner, Alex C (2017) Understanding the molecular functions of the second extracellular loop (ECL2) of the calcitonin gene-related peptide (CGRP) receptor using a comprehensive mutagenesis approach. Molecular and Cellular Endocrinology, 454 (C). pp. 39-49. DOI https://doi.org/10.1016/j.mce.2017.05.034
Wootten, Denise and Reynolds, Christopher A and Smith, Kevin J and Mobarec, Juan C and Koole, Cassandra and Savage, Emilia E and Pabreja, Kavita and Simms, John and Sridhar, Rohan and Furness, Sebastian GB and Liu, Mengjie and Thompson, Philip E and Miller, Laurence J and Christopoulos, Arthur and Sexton, Patrick M (2016) The Extracellular Surface of the GLP-1 Receptor Is a Molecular Trigger for Biased Agonism. Cell, 165 (7). pp. 1632-1643. DOI https://doi.org/10.1016/j.cell.2016.05.023
Wootten, Denise and Reynolds, Christopher A and Koole, Cassandra and Smith, Kevin J and Mobarec, Juan C and Simms, John and Quon, Tezz and Coudrat, Thomas and Furness, Sebastian GB and Miller, Laurence J and Christopoulos, Arthur and Sexton, Patrick M (2016) A Hydrogen-Bonded Polar Network in the Core of the Glucagon-Like Peptide-1 Receptor Is a Fulcrum for Biased Agonism: Lessons from Class B Crystal Structures. Molecular Pharmacology, 89 (3). pp. 335-347. DOI https://doi.org/10.1124/mol.115.101246