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Towards high resolution maps of the mouse and human genomes?a facility for ordering markers to 0.1 cM resolution

Breen, M and Deakin, L and Macdonald, B and Miller, S and Sibson, R and Tarttelin, E and Avner, P and Bourgade, F and Guenet, JL and Montagutelli, X and Poirier, C and Simon, D and Tailor, D and Bishop, M and Kelly, M and Rysavy, F and Rastan, S and Norris, D and Shepherd, D and Abbott, C and Pilz, A and Hodge, S and Jackson, I and Boyd, Y and Blair, H and Maslen, G and Todd, JA and Reed, PW and Stoye, J and Ashworth, A and McCarthy, L and Cox, R and Schalkwyk, LC and Lehrach, H and Klose, J and Gangadharan, U and Brown, S (1994) 'Towards high resolution maps of the mouse and human genomes?a facility for ordering markers to 0.1 cM resolution.' Human Molecular Genetics, 3 (4). pp. 621-627. ISSN 0964-6906

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982 progeny produced by a mouse Interspecific backcross between C57BL/6 and Mus spretus have been scored for at least 3 markers on each chromosome, completing an anchor map of 78 loci across the mouse genome. The anchor mapping identifies all the available recomblnants in each interanchor Interval allowing access to panels of mice that can be used for the high resolution mapping of any chromosome region. The large number of progeny recovered and scored from the Interspecific backcross allows us to resolve genetically markers that lie on average 200 kb apart on mouse chromosomes and within the cloning capacity of currently available YAC libraries. EUCIB provides the first genetic mapping resource specifically designed for the high resolution mapping of all regions of the mouse genome and will underpin the global physical mapping of the mouse genome. In addition, with the use of conserved sequences the facility is applicable to the high resolution comparative mapping of the mouse and human genomes. A new database has been implemented to support the computation of high resolution and ordered genetic maps.

Item Type: Article
Uncontrolled Keywords: Animals; Mice, Inbred C57BL; Humans; Muridae; Mice; Genetic Markers; Chromosome Mapping; Crosses, Genetic; Hybridization, Genetic; Lod Score; Genome; Genome, Human; Databases, Factual; Female; Male
Subjects: Q Science > QH Natural history > QH426 Genetics
Divisions: Faculty of Science and Health
Faculty of Science and Health > Life Sciences, School of
SWORD Depositor: Elements
Depositing User: Elements
Date Deposited: 02 Aug 2017 18:25
Last Modified: 15 Jan 2022 00:49

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