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The Collaborative Cross, a community resource for the genetic analysis of complex traits

Churchill, GA and Airey, DC and Allayee, H and Angel, JM and Attie, AD and Beatty, J and Beavis, WD and Belknap, JK and Bennett, B and Berrettini, W and Bleich, A and Bogue, M and Broman, KW and Buck, KJ and Buckler, E and Burmeister, M and Chesler, EJ and Cheverud, JM and Clapcote, S and Cook, MN and Cox, RD and Crabbe, JC and Crusio, WE and Darvasi, A and Deschepper, CF and Doerge, RW and Farber, CR and Forejt, J and Gaile, D and Garlow, SJ and Geiger, H and Gershenfeld, H and Gordon, T and Gu, J and Gu, W and de Haan, G and Hayes, NL and Heller, C and Himmelbauer, H and Hitzemann, R and Hunter, K and Hsu, HC and Iraqi, FA and Ivandic, B and Jacob, HJ and Jansen, RC and Jepsen, KJ and Johnson, DK and Johnson, TE and Kempermann, G and Kendziorski, C and Kotb, M and Kooy, RF and Llamas, B and Lammert, F and Lassalle, JM and Lowenstein, PR and Lu, L and Lusis, A and Manly, KF and Marcucio, R and Matthews, D and Medrano, JF and Miller, DR and Mittleman, G and Mock, BA and Mogil, JS and Montagutelli, X and Morahan, G and Morris, DG and Mott, R and Nadeau, JH and Nagase, H and Nowakowski, RS and O'Hara, BF and Osadchuk, AV and Page, GP and Paigen, B and Paigen, K and Palmer, AA and Pan, HJ and Peltonen-Palotie, L and Peirce, J and Pomp, D and Pravenec, M and Prows, DR and Qi, Z and Reeves, RH and Roder, J and Rosen, GD and Schadt, EE and Schalkwyk, LC and Seltzer, Z and Shimomura, K and Shou, S and Sillanpää, MJ and Siracusa, LD and Snoeck, HW and Spearow, JL (2004) 'The Collaborative Cross, a community resource for the genetic analysis of complex traits.' Nature Genetics, 36 (11). 1133 - 1137. ISSN 1061-4036

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Abstract

The goal of the Complex Trait Consortium is to promote the development of resources that can be used to understand, treat and ultimately prevent pervasive human diseases. Existing and proposed mouse resources that are optimized to study the actions of isolated genetic loci on a fixed background are less effective for studying intact polygenic networks and interactions among genes, environments, pathogens and other factors. The Collaborative Cross will provide a common reference panel specifically designed for the integrative analysis of complex systems and will change the way we approach human health and disease.

Item Type: Article
Subjects: Q Science > QH Natural history > QH426 Genetics
Divisions: Faculty of Science and Health > Biological Sciences, School of
Depositing User: Jim Jamieson
Date Deposited: 14 Feb 2015 20:15
Last Modified: 17 Aug 2017 17:46
URI: http://repository.essex.ac.uk/id/eprint/11002

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