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Cross-region reduction in 5-hydroxymethylcytosine in Alzheimer's disease brain

Condliffe, D and Wong, A and Troakes, C and Proitsi, P and Patel, Y and Chouliaras, L and Fernandes, C and Cooper, J and Lovestone, S and Schalkwyk, L and Mill, J and Lunnon, K (2014) 'Cross-region reduction in 5-hydroxymethylcytosine in Alzheimer's disease brain.' Neurobiology of Aging, 35 (8). 1850 - 1854. ISSN 0197-4580

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Abstract

Epigenetic processes play a key role in the central nervous system and altered levels of 5-methylcytosine have been associated with a number of neurologic phenotypes, including Alzheimer's disease (AD). Recently, 3 additional cytosine modifications have been identified (5-hydroxymethylcytosine, 5-formylcytosine, and 5-carboxylcytosine), which are thought to be intermediate steps in the demethylation of 5-methylcytosine to unmodified cytosine. Little is known about the frequency of these modifications in the human brain during health or disease. In this study, we used immunofluorescence to confirm the presence of each modification in human brain and investigate their cross-tissue abundance in AD patients and elderly control samples. We identify a significant AD-associated decrease in global 5-hydroxymethylcytosine in entorhinal cortex and cerebellum, and differences in 5-formylcytosine levels between brain regions. Our study further implicates a role for epigenetic alterations in AD. © 2014 Elsevier Inc.

Item Type: Article
Subjects: Q Science > QH Natural history > QH426 Genetics
Divisions: Faculty of Science and Health > Biological Sciences, School of
Depositing User: Jim Jamieson
Date Deposited: 24 Oct 2014 13:36
Last Modified: 17 Aug 2017 17:46
URI: http://repository.essex.ac.uk/id/eprint/11006

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