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Hippocampal gene expression profiling across eight mouse inbred strains: towards understanding the molecular basis for behaviour

Fernandes, Cathy and Paya-Cano, Jose L and Sluyter, Frans and D'Souza, Ursula and Plomin, Robert and Schalkwyk, Leonard C (2004) 'Hippocampal gene expression profiling across eight mouse inbred strains: towards understanding the molecular basis for behaviour.' European Journal of Neuroscience, 19 (9). pp. 2576-2582. ISSN 0953-816X

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Mouse inbred strains differ in many aspects of their phenotypes, and it is known that gene expression does so too. This gives us an opportunity to isolate the genetic aspect of variation in expression and compare it to other phenotypic variables. We have investigated these issues using an eight-strain expression profile comparison with four replicates per strain on Affymetrix MGU74av2 GeneChips focusing on one well-defined brain tissue (the hippocampus). We identified substantial strain-specific variation in hippocampal gene expression, with more than two hundred genes showing strain differences by a very conservative criterion. Many such genetically driven differences in gene expression are likely to result in functional differences including differences in behaviour. A large panel of inbred strains could be used to identify genes functionally involved in particular phenotypes, similar to genetic correlation. The genetic correlation between expression profiles and function is potentially very powerful, especially given the current large-scale generation of phenotypic data on multiple strains (the Mouse Phenome Project). As an example, the strongest genetic correlation between more than 200 probe sets showing significant differences among our eight inbred strains and a ranking of these strains by aggression phenotype was found for Comt, a gene known to be involved in aggression.

Item Type: Article
Uncontrolled Keywords: expression correlation; microarray
Subjects: Q Science > QH Natural history > QH426 Genetics
Divisions: Faculty of Science and Health
Faculty of Science and Health > Life Sciences, School of
SWORD Depositor: Elements
Depositing User: Elements
Date Deposited: 14 Feb 2015 20:27
Last Modified: 15 Jan 2022 00:42

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