Research Repository

Assessing reliability, heritability and general cognitive ability in a battery of cognitive tasks for laboratory mice

Galsworthy, MJ and Paya-Cano, JL and Liu, L and Monleón, S and Gregoryan, G and Fernandes, C and Schalkwyk, LC and Plomin, R (2005) 'Assessing reliability, heritability and general cognitive ability in a battery of cognitive tasks for laboratory mice.' Behavior Genetics, 35 (5). 675 - 692. ISSN 0001-8244

Full text not available from this repository.

Abstract

This report includes the first sibling study of mouse behavior, and presents evidence for a heritable general cognitive ability (g) factor influencing cognitive batteries. Data from a population of male and female outbred mice (n = 84), and a replication study of male sibling pairs (n = 167) are reported. Arenas employed were the T-maze, the Morris water maze, the puzzle box, the Hebb-Williams maze, object exploration, a water plus-maze, and a second food-puzzle arena. The results show a factor structure consistent with the presence of g in mice. Employing one score per arena, this factor accounts for 41% of the variance in the first study (or 36% after sex regression) and 23% in the second, where this factor also showed sibling correlations of 0.17-0.21, which translates into an upper-limit heritability estimate of around 40%. Reliabilities of many tasks are low and consequently set an even lower ceiling for inter-arena or sibling correlations. Nevertheless, the factor structure is seen to remain fairly robust across permutations of the battery composition and the current findings fit well with other recent studies. © 2005 Springer Science+Business Media, Inc.

Item Type: Article
Subjects: Q Science > QH Natural history > QH426 Genetics
Divisions: Faculty of Science and Health > Biological Sciences, School of
Depositing User: Jim Jamieson
Date Deposited: 30 Jan 2015 12:14
Last Modified: 17 Aug 2017 17:46
URI: http://repository.essex.ac.uk/id/eprint/11029

Actions (login required)

View Item View Item