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Assessing Reliability, Heritability and General Cognitive Ability in a Battery of Cognitive Tasks for Laboratory Mice

Galsworthy, Michael J and Paya-Cano, Jose L and Liu, Lin and Monleón, Santiago and Gregoryan, Gregory and Fernandes, Cathy and Schalkwyk, Leonard C and Plomin, Robert (2005) 'Assessing Reliability, Heritability and General Cognitive Ability in a Battery of Cognitive Tasks for Laboratory Mice.' Behavior Genetics, 35 (5). pp. 675-692. ISSN 0001-8244

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This report includes the first sibling study of mouse behavior, and presents evidence for a heritable general cognitive ability (g) factor influencing cognitive batteries. Data from a population of male and female outbred mice (n = 84), and a replication study of male sibling pairs (n = 167) are reported. Arenas employed were the T-maze, the Morris water maze, the puzzle box, the Hebb-Williams maze, object exploration, a water plus-maze, and a second food-puzzle arena. The results show a factor structure consistent with the presence of g in mice. Employing one score per arena, this factor accounts for 41% of the variance in the first study (or 36% after sex regression) and 23% in the second, where this factor also showed sibling correlations of 0.17-0.21, which translates into an upper-limit heritability estimate of around 40%. Reliabilities of many tasks are low and consequently set an even lower ceiling for inter-arena or sibling correlations. Nevertheless, the factor structure is seen to remain fairly robust across permutations of the battery composition and the current findings fit well with other recent studies. © 2005 Springer Science+Business Media, Inc.

Item Type: Article
Uncontrolled Keywords: factor analysis; g; general cognitive ability; heritability; HS mice; individual differences; siblings
Subjects: Q Science > QH Natural history > QH426 Genetics
Divisions: Faculty of Science and Health
Faculty of Science and Health > Life Sciences, School of
SWORD Depositor: Elements
Depositing User: Elements
Date Deposited: 30 Jan 2015 12:14
Last Modified: 15 Jan 2022 00:42

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