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Genetics of behavioural domains across the neuropsychiatric spectrum; of mice and men

Kas, MJH and Fernandes, C and Schalkwyk, LC and Collier, DA (2007) 'Genetics of behavioural domains across the neuropsychiatric spectrum; of mice and men.' Molecular Psychiatry, 12 (4). pp. 324-330. ISSN 1359-4184

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Family and twin studies have revealed that genetic factors play a major role in psychiatric disorders, however, attempts to find susceptibility genes for these complex disorders have been largely unsuccessful. Therefore, new research strategies are required to tackle the complex interactions of genes, developmental, and environmental events. Here, we will address a behavioural domain concept that focuses on the genetics of behavioural domains relevant to both animal behaviour and across human psychiatric disorders. We believe that interspecies trait genetics rather than complex syndrome genetics will optimize genotype-phenotype relationships for psychiatric disorders and facilitate the identification of biological substrates underlying these disorders. © 2007 Nature Publishing Group All rights reserved.

Item Type: Article
Uncontrolled Keywords: psychiatry; animal models; human; endophenotype; behaviour; environment
Subjects: Q Science > QH Natural history > QH426 Genetics
Divisions: Faculty of Science and Health
Faculty of Science and Health > Life Sciences, School of
SWORD Depositor: Elements
Depositing User: Elements
Date Deposited: 17 Dec 2014 19:26
Last Modified: 18 Aug 2022 12:08

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