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A Genome-Wide Association Study of Social and Non-Social Autistic-Like Traits in the General Population Using Pooled DNA, 500 K SNP Microarrays and Both Community and Diagnosed Autism Replication Samples

Ronald, Angelica and Butcher, Lee M and Docherty, Sophia and Davis, Oliver SP and Schalkwyk, Leonard C and Craig, Ian W and Plomin, Robert (2010) 'A Genome-Wide Association Study of Social and Non-Social Autistic-Like Traits in the General Population Using Pooled DNA, 500 K SNP Microarrays and Both Community and Diagnosed Autism Replication Samples.' Behavior Genetics, 40 (1). pp. 31-45. ISSN 0001-8244

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Abstract

Two separate genome-wide association studies were conducted to identify single nucleotide polymorphisms (SNPs) associated with social and nonsocial autistic- like traits. We predicted that we would find SNPs associated with social and non-social autistic-like traits and that different SNPs would be associated with social and nonsocial. In Stage 1, each study screened for allele frequency differences in ∼430,000 autosomal SNPs using pooled DNA on microarrays in high-scoring versus lowscoring boys from a general population sample (N = ∼400/group). In Stage 2, 22 and 20 SNPs in the social and non-social studies, respectively, were tested for QTL association by individually genotyping an independent community sample of 1,400 boys. One SNP (rs11894053) was nominally associated (P<.05, uncorrected for multiple testing) with social autistic-like traits. When the sample was increased by adding females, 2 additional SNPs were nominally significant (P<.05). These 3 SNPs, however, showed no significant association in transmission disequilibrium analyses of diagnosed ASD families. © 2009 Springer Science+Business Media, LLC.

Item Type: Article
Uncontrolled Keywords: Autistic traits; Genome-wide association; Autism; Microarrays; Heritability; Pooling
Subjects: Q Science > QH Natural history > QH426 Genetics
Divisions: Faculty of Science and Health
Faculty of Science and Health > Life Sciences, School of
SWORD Depositor: Elements
Depositing User: Elements
Date Deposited: 23 Oct 2014 12:43
Last Modified: 15 Jan 2022 00:49
URI: http://repository.essex.ac.uk/id/eprint/11098

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