Research Repository

Refined radiation hybrid map of mouse Chromosome 17

Schalkwyk, LC and Weiher, M and Kirby, M and Cusack, B and Himmelbauer, H and Lehrach, H (1998) 'Refined radiation hybrid map of mouse Chromosome 17.' Mammalian Genome, 9 (10). 807 - 811. ISSN 0938-8990

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We have made a radiation hybrid map of mouse Chromosome (Chr) 17 with 75 microsatellite markers, including those from McCarthy et al. (Genome Res 7, 1153-1161, 1997). Seventy-four of the markers are linked at LOD > 9, and all link at LOD > 5. A LOD 3 framework of 18 markers was used to construct a placement map. The order obtained is in good agreement with genetic maps, and distance estimates give an idea of how recombination rates vary across the chromosome. Recombination is remarkably low with respect to RH break frequency in the region from the centromere to the end of H2. This is similar in interspecific and intersubspecific crosses despite the inversion of a substantial part of this region in Mus spretus with respect to Mus musculus.

Item Type: Article
Subjects: Q Science > QH Natural history > QH426 Genetics
Divisions: Faculty of Science and Health > Life Sciences, School of
Depositing User: Jim Jamieson
Date Deposited: 02 Aug 2017 08:47
Last Modified: 17 Sep 2019 11:15

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