Research Repository

Transcriptomic changes in the frontal cortex associated with paternal age

Smith, RG and Fernandes, C and Kember, R and Schalkwyk, LC and Buxbaum, J and Reichenberg, A and Mill, J (2014) 'Transcriptomic changes in the frontal cortex associated with paternal age.' Molecular Autism, 5 (1). ISSN 2040-2392

[img]
Preview
Text
2040-2392-5-24.pdf - Published Version
Available under License Creative Commons Attribution.

Download (625kB) | Preview

Abstract

Background: Advanced paternal age is robustly associated with several human neuropsychiatric disorders, particularly autism. The precise mechanism(s) mediating the paternal age effect are not known, but they are thought to involve the accumulation of de novo (epi)genomic alterations. In this study we investigate differences in the frontal cortex transcriptome in a mouse model of advanced paternal age. Findings. Transcriptomic profiling was undertaken for medial prefrontal cortex tissue dissected from the male offspring of young fathers (2 month old, 4 sires, n = 16 offspring) and old fathers (10 month old, 6 sires, n = 16 offspring) in a mouse model of advancing paternal age. We found a number of differentially expressed genes in the offspring of older fathers, many previously implicated in the aetiology of autism. Pathway analysis highlighted significant enrichment for changes in functional networks involved in inflammation and inflammatory disease, which are also implicated in autism. Conclusions: We observed widespread alterations to the transcriptome associated with advanced paternal age with an enrichment of genes associated with inflammation, an interesting observation given previous evidence linking the immune system to several neuropsychiatric disorders including autism. © 2014 Smith et al.; licensee BioMed Central Ltd.

Item Type: Article
Subjects: Q Science > QH Natural history > QH426 Genetics
Divisions: Faculty of Science and Health > Biological Sciences, School of
Depositing User: Jim Jamieson
Date Deposited: 29 Oct 2014 10:27
Last Modified: 17 Aug 2017 17:46
URI: http://repository.essex.ac.uk/id/eprint/11114

Actions (login required)

View Item View Item