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Alcohol consumption and cognitive performance: A mendelian randomization study

Kumari, M and Holmes, MV and Dale, CE and Hubacek, JA and Palmer, TM and Pikhart, H and Peasey, A and Britton, A and Horvat, P and Kubinova, R and Malyutina, S and Pajak, A and Tamosiunas, A and Shankar, A and Singh-Manoux, A and Voevoda, M and Kivimaki, M and Hingorani, AD and Marmot, MG and Casas, JP and Bobak, M (2014) 'Alcohol consumption and cognitive performance: A mendelian randomization study.' Addiction, 109 (9). 1462 - 1471. ISSN 0965-2140

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Abstract

© 2014 The Authors. Addiction published by John Wiley & Sons Ltd on behalf of Society for the Study of Addiction. Aims: To use Mendelian randomization to assess whether alcohol intake was causally associated with cognitive function. Design: Mendelian randomization using a genetic variant related to alcohol intake (ADH1B rs1229984) was used to obtain unbiased estimates of the association between alcohol intake and cognitive performance. Setting: Europe. Participants: More than 34000 adults. Measurements: Any versus no alcohol intake and units of intake in the previous week was measured by questionnaire. Cognitive function was assessed in terms of immediate and delayed word recall, verbal fluency and processing speed. Findings: Having consumed any versus no alcohol was associated with higher scores by 0.17 standard deviations (SD) [95% confidence interval (CI)=0.15, 0.20] for immediate recall, 0.17 SD (95% CI=0.14, 0.19) for delayed recall, 0.17 SD (95% CI=0.14, 0.19) for verbal fluency and 0.12 SD (95% CI=0.09, 0.15) for processing speed. The minor allele of rs1229984 was associated with reduced odds of consuming any alcohol (odds ratio=0.87; 95% CI=0.80, 0.95; P=0.001; R<sup>2</sup>=0.1%; F-statistic=47). In Mendelian randomization analysis, the minor allele was not associated with any cognitive test score, and instrumental variable analysis suggested no causal association between alcohol consumption and cognition: -0.74 SD (95% CI=-1.88, 0.41) for immediate recall, -1.09 SD (95% CI=-2.38, 0.21) for delayed recall, -0.63 SD (95% CI=-1.78, 0.53) for verbal fluency and -0.16 SD (95% CI=-1.29, 0.97) for processing speed. Conclusions: The Mendelian randomization analysis did not provide strong evidence of a causal association between alcohol consumption and cognitive ability.

Item Type: Article
Subjects: H Social Sciences > H Social Sciences (General)
H Social Sciences > HA Statistics
R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine
Divisions: Faculty of Social Sciences > Institute for Social and Economic Research
Depositing User: Jim Jamieson
Date Deposited: 06 Feb 2015 14:09
Last Modified: 23 Jan 2019 01:15
URI: http://repository.essex.ac.uk/id/eprint/12671

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