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Genome-wide scan demonstrates significant linkage for male sexual orientation

Sanders, AR and Martin, ER and Beecham, GW and Guo, S and Dawood, K and Rieger, G and Badner, JA and Gershon, ES and Krishnappa, RS and Kolundzija, AB and Duan, J and Gejman, PV and Bailey, JM (2015) 'Genome-wide scan demonstrates significant linkage for male sexual orientation.' Psychological Medicine, 45 (7). pp. 1379-1388. ISSN 0033-2917

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Abstract

<jats:sec id="S0033291714002451_sec_a1"><jats:title>Background</jats:title><jats:p>Findings from family and twin studies support a genetic contribution to the development of sexual orientation in men. However, previous studies have yielded conflicting evidence for linkage to chromosome Xq28.</jats:p></jats:sec><jats:sec id="S0033291714002451_sec_a2" sec-type="methods"><jats:title>Method</jats:title><jats:p>We conducted a genome-wide linkage scan on 409 independent pairs of homosexual brothers (908 analyzed individuals in 384 families), by far the largest study of its kind to date.</jats:p></jats:sec><jats:sec id="S0033291714002451_sec_a3" sec-type="results"><jats:title>Results</jats:title><jats:p>We identified two regions of linkage: the pericentromeric region on chromosome 8 (maximum two-point LOD = 4.08, maximum multipoint LOD = 2.59), which overlaps with the second strongest region from a previous separate linkage scan of 155 brother pairs; and Xq28 (maximum two-point LOD = 2.99, maximum multipoint LOD = 2.76), which was also implicated in prior research.</jats:p></jats:sec><jats:sec id="S0033291714002451_sec_a4" sec-type="conclusion"><jats:title>Conclusions</jats:title><jats:p>Results, especially in the context of past studies, support the existence of genes on pericentromeric chromosome 8 and chromosome Xq28 influencing development of male sexual orientation.</jats:p></jats:sec>

Item Type: Article
Uncontrolled Keywords: Chromosome 8; chromosome Xq28; complex trait; genome-wide linkage scan; human; male sexual orientation
Subjects: B Philosophy. Psychology. Religion > BF Psychology
Divisions: Faculty of Science and Health
Faculty of Science and Health > Psychology, Department of
SWORD Depositor: Elements
Depositing User: Elements
Date Deposited: 24 Mar 2015 11:42
Last Modified: 15 Jan 2022 00:31
URI: http://repository.essex.ac.uk/id/eprint/13306

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