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Genome-wide scan demonstrates significant linkage for male sexual orientation

Sanders, AR and Martin, ER and Beecham, GW and Guo, S and Dawood, K and Rieger, G and Badner, JA and Gershon, ES and Krishnappa, RS and Kolundzija, AB and Duan, J and Gejman, PV and Bailey, JM (2015) 'Genome-wide scan demonstrates significant linkage for male sexual orientation.' Psychological Medicine, 45 (7). 1379 - 1388. ISSN 0033-2917

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Abstract

Copyright © Cambridge University Press 2014. Background Findings from family and twin studies support a genetic contribution to the development of sexual orientation in men. However, previous studies have yielded conflicting evidence for linkage to chromosome Xq28. Method We conducted a genome-wide linkage scan on 409 independent pairs of homosexual brothers (908 analyzed individuals in 384 families), by far the largest study of its kind to date. Results We identified two regions of linkage: the pericentromeric region on chromosome 8 (maximum two-point LOD = 4.08, maximum multipoint LOD = 2.59), which overlaps with the second strongest region from a previous separate linkage scan of 155 brother pairs; and Xq28 (maximum two-point LOD = 2.99, maximum multipoint LOD = 2.76), which was also implicated in prior research. Conclusions Results, especially in the context of past studies, support the existence of genes on pericentromeric chromosome 8 and chromosome Xq28 influencing development of male sexual orientation.

Item Type: Article
Subjects: B Philosophy. Psychology. Religion > BF Psychology
Divisions: Faculty of Science and Health > Psychology, Department of
Depositing User: Users 161 not found.
Date Deposited: 24 Mar 2015 11:42
Last Modified: 30 Jan 2019 16:19
URI: http://repository.essex.ac.uk/id/eprint/13306

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