Genome-wide scan demonstrates significant linkage for male sexual orientation

<jats:sec id="S0033291714002451_sec_a1"><jats:title>Background</jats:title><jats:p>Findings from family and twin studies support a genetic contribution to the development of sexual orientation in men. However, previous studies have yielded conflicting evidence for linkage to chromosome Xq28.</jats:p></jats:sec><jats:sec id="S0033291714002451_sec_a2" sec-type="methods"><jats:title>Method</jats:title><jats:p>We conducted a genome-wide linkage scan on 409 independent pairs of homosexual brothers (908 analyzed individuals in 384 families), by far the largest study of its kind to date.</jats:p></jats:sec><jats:sec id="S0033291714002451_sec_a3" sec-type="results"><jats:title>Results</jats:title><jats:p>We identified two regions of linkage: the pericentromeric region on chromosome 8 (maximum two-point LOD = 4.08, maximum multipoint LOD = 2.59), which overlaps with the second strongest region from a previous separate linkage scan of 155 brother pairs; and Xq28 (maximum two-point LOD = 2.99, maximum multipoint LOD = 2.76), which was also implicated in prior research.</jats:p></jats:sec><jats:sec id="S0033291714002451_sec_a4" sec-type="conclusion"><jats:title>Conclusions</jats:title><jats:p>Results, especially in the context of past studies, support the existence of genes on pericentromeric chromosome 8 and chromosome Xq28 influencing development of male sexual orientation.</jats:p></jats:sec>