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Hexadentate 3-hydroxypyridin-4-ones with high iron(III) affinity: Design, synthesis and inhibition on methicillin resistant Staphylococcus aureus and Pseudomonas strains

Zhou, Y and Liu, M and Osamah, AR and Kong, X and Alsam, S and Battah, S and Xie, Y and Hider, RC and Zhou, T (2015) 'Hexadentate 3-hydroxypyridin-4-ones with high iron(III) affinity: Design, synthesis and inhibition on methicillin resistant Staphylococcus aureus and Pseudomonas strains.' European Journal of Medicinal Chemistry, 94. 8 - 21. ISSN 0009-4374

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Abstract

A range of hexadentate 3-hydroxypyridin-4-ones have been synthesized. These compounds were found to possess a high affinity for iron(III), with logK1 values of about 34 and pFe values over 30. Antimicrobial assays indicated that they can inhibit the growth of three clinical isolates of methicillin resistant Staphylococcus aureus (MRSA) and three clinical isolates of Pseudomonas, suggesting that hexadentate 3-hydroxypyridin-4-ones have potential application in the treatment of wound infections.

Item Type: Article
Uncontrolled Keywords: Pseudomonas aeruginosa
Subjects: Q Science > Q Science (General)
Divisions: Faculty of Science and Health > Biological Sciences, School of
Depositing User: Jim Jamieson
Date Deposited: 13 Apr 2015 13:49
Last Modified: 24 Nov 2017 14:15
URI: http://repository.essex.ac.uk/id/eprint/13503

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