Zhou, Y and Liu, M and Osamah, AR and Kong, X and Alsam, S and Battah, S and Xie, Y and Hider, RC and Zhou, T (2015) Hexadentate 3-hydroxypyridin-4-ones with high iron(III) affinity: Design, synthesis and inhibition on methicillin resistant Staphylococcus aureus and Pseudomonas strains. European Journal of Medicinal Chemistry, 94. pp. 8-21. DOI https://doi.org/10.1016/j.ejmech.2015.02.050
Zhou, Y and Liu, M and Osamah, AR and Kong, X and Alsam, S and Battah, S and Xie, Y and Hider, RC and Zhou, T (2015) Hexadentate 3-hydroxypyridin-4-ones with high iron(III) affinity: Design, synthesis and inhibition on methicillin resistant Staphylococcus aureus and Pseudomonas strains. European Journal of Medicinal Chemistry, 94. pp. 8-21. DOI https://doi.org/10.1016/j.ejmech.2015.02.050
Zhou, Y and Liu, M and Osamah, AR and Kong, X and Alsam, S and Battah, S and Xie, Y and Hider, RC and Zhou, T (2015) Hexadentate 3-hydroxypyridin-4-ones with high iron(III) affinity: Design, synthesis and inhibition on methicillin resistant Staphylococcus aureus and Pseudomonas strains. European Journal of Medicinal Chemistry, 94. pp. 8-21. DOI https://doi.org/10.1016/j.ejmech.2015.02.050
Abstract
A range of hexadentate 3-hydroxypyridin-4-ones have been synthesized. These compounds were found to possess a high affinity for iron(III), with logK1 values of about 34 and pFe values over 30. Antimicrobial assays indicated that they can inhibit the growth of three clinical isolates of methicillin resistant Staphylococcus aureus (MRSA) and three clinical isolates of Pseudomonas, suggesting that hexadentate 3-hydroxypyridin-4-ones have potential application in the treatment of wound infections.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Pseudomonas aeruginosa |
| Subjects: | Q Science > Q Science (General) |
| Divisions: | Faculty of Science and Health Faculty of Science and Health > Life Sciences, School of |
| SWORD Depositor: | Unnamed user with email elements@essex.ac.uk |
| Depositing User: | Unnamed user with email elements@essex.ac.uk |
| Date Deposited: | 13 Apr 2015 13:49 |
| Last Modified: | 06 Jan 2022 13:17 |
| URI: | http://repository.essex.ac.uk/id/eprint/13503 |