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Change in Sleep Duration and Type 2 Diabetes: The Whitehall II Study

Ferrie, Jane E and Kivimäki, Mika and Akbaraly, Tasnime N and Tabak, Adam and Abell, Jessica and Davey Smith, George and Virtanen, Marianna and Kumari, Meena and Shipley, Martin J (2015) 'Change in Sleep Duration and Type 2 Diabetes: The Whitehall II Study.' Diabetes Care, 38 (8). pp. 1467-1472. ISSN 0149-5992


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<jats:sec> <jats:title>OBJECTIVE</jats:title> <jats:p>Evidence suggests that short and long sleep durations are associated with a higher risk of type 2 diabetes. Using successive data waves spanning &amp;gt;20 years, we examined whether a change in sleep duration is associated with incident diabetes.</jats:p> </jats:sec> <jats:sec> <jats:title>RESEARCH DESIGN AND METHODS</jats:title> <jats:p>Sleep duration was reported at the beginning and end of four 5-year cycles: 1985–1988 to 1991–1994 (n = 5,613), 1991–1994 to 1997–1999 (n = 4,193), 1997–1999 to 2002–2004 (n = 3,840), and 2002–2004 to 2007–2009 (n = 4,195). At each cycle, change in sleep duration was calculated for participants without diabetes. Incident diabetes at the end of the subsequent 5-year period was defined using 1) fasting glucose, 2) 75-g oral glucose tolerance test, and 3) glycated hemoglobin, in conjunction with diabetes medication and self-reported doctor diagnosis.</jats:p> </jats:sec> <jats:sec> <jats:title>RESULTS</jats:title> <jats:p>Compared with the reference group of persistent 7-h sleepers, an increase of ≥2 h sleep per night was associated with a higher risk of incident diabetes (odds ratio 1.65 [95% CI 1.15, 2.37]) in analyses adjusted for age, sex, employment grade, and ethnic group. This association was partially attenuated by adjustment for BMI and change in weight (1.50 [1.04, 2.16]). An increased risk of incident diabetes was also seen in persistent short sleepers (average ≤5.5 h/night; 1.35 [1.04, 1.76]), but this evidence weakened on adjustment for BMI and change in weight (1.25 [0.96, 1.63]).</jats:p> </jats:sec> <jats:sec> <jats:title>CONCLUSIONS</jats:title> <jats:p>This study suggests that individuals whose sleep duration increases are at an increased risk of type 2 diabetes. Greater weight and weight gain in this group partly explain the association.</jats:p> </jats:sec>

Item Type: Article
Uncontrolled Keywords: Humans; Diabetes Mellitus, Type 2; Weight Gain; Glucose Tolerance Test; Fasting; Risk Factors; Prospective Studies; Time Factors; Adult; Middle Aged; London; Female; Male; Sleep Wake Disorders; Glycated Hemoglobin A
Subjects: H Social Sciences > H Social Sciences (General)
R Medicine > R Medicine (General)
Divisions: Faculty of Social Sciences
Faculty of Social Sciences > Institute for Social and Economic Research
SWORD Depositor: Elements
Depositing User: Elements
Date Deposited: 20 Aug 2015 19:12
Last Modified: 18 Aug 2022 11:08

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