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Adult height, coronary heart disease and stroke: A multi-locus Mendelian randomization meta-analysis

Nüesch, E and Dale, C and Palmer, TM and White, J and Keating, BJ and van Iperen, EPA and Goel, A and Padmanabhan, S and Asselbergs, FW and Verschuren, WM and Wijmenga, C and Van der Schouw, YT and Onland-Moret, NC and Lange, LA and Hovingh, GK and Sivapalaratnam, S and Morris, RW and Whincup, PH and Wannamethe, GS and Gaunt, TR and Ebrahim, S and Steel, L and Nair, N and Reiner, AP and Kooperberg, C and Wilson, JF and Bolton, JL and McLachlan, S and Price, JF and Strachan, MWJ and Robertson, CM and Kleber, ME and Delgado, G and März, W and Melander, O and Dominiczak, AF and Farrall, M and Watkins, H and Leusink, M and Maitland-van der Zee, AH and de Groot, MCH and Dudbridge, F and Hingorani, A and Ben-Shlomo, Y and Lawlor, DA and Amuzu, A and Caufield, M and Cavadino, A and Cooper, J and Davies, TL and Day, IN and Drenos, F and Engmann, J and Finan, C and Giambartolomei, C and Hardy, R and Humphries, SE and Hypponen, E and Kivimaki, M and Kuh, D and Kumari, M and Ong, K and Plagnol, V and Power, C and Richards, M and Shah, S and Shah, T and Sofat, R and Talmud, PJ and Wareham, N and Warren, H and Whittaker, JC and Wong, A and Zabaneh, D and Smith, GD and Wells, JC and Leon, DA and Holmes, MV and Casas, JP (2016) 'Adult height, coronary heart disease and stroke: A multi-locus Mendelian randomization meta-analysis.' International Journal of Epidemiology, 45 (6). 1927 - 1937. ISSN 0300-5771

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Abstract

© The Author 2015; all rights reserved. Background: We investigated causal effect of completed growth, measured by adult height, on coronary heart disease (CHD), stroke and cardiovascular traits, using instrumental variable (IV) Mendelian randomization meta-analysis. Methods: We developed an allele score based on 69 single nucleotide polymorphisms (SNPs) associated with adult height, identified by the IBCCardioChip, and used it for IV analysis against cardiovascular risk factors and events in 21 studies and 60 028 participants. IV analysis on CHD was supplemented by summary data from 180 height-SNPs from the GIANT consortium and their corresponding CHD estimates derived from CARDIoGRAMplusC4D. Results: IV estimates from IBCCardioChip and GIANT-CARDIoGRAMplusC4D showed that a 6.5-cm increase in height reduced the odds of CHD by 10% [odds ratios 0.90; 95% confidence intervals (CIs): 0.78 to 1.03 and 0.85 to 0.95, respectively],which agrees with the estimate from the Emerging Risk Factors Collaboration (hazard ratio 0.93; 95% CI: 0.91 to 0.94). IV analysis revealed no association with stroke (odds ratio 0.97; 95% CI: 0.79 to 1.19). IV analysis showed that a 6.5-cm increase in height resulted in lower levels of body mass index (P < 0.001), triglycerides (P < 0.001), non high-density (non-HDL) cholesterol (P < 0.001), C-reactive protein (P = 0.042), and systolic blood pressure (P = 0.064) and higher levels of forced expiratory volume in 1 s and forced vital capacity (P < 0.001 for both). Conclusions: Taller individuals have a lower risk of CHD with potential explanations being that taller people have a better lung function and lower levels of body mass index, cholesterol and blood pressure.

Item Type: Article
Subjects: H Social Sciences > H Social Sciences (General)
R Medicine > R Medicine (General)
Divisions: Faculty of Social Sciences > Institute for Social and Economic Research
Depositing User: Jim Jamieson
Date Deposited: 29 Sep 2015 11:00
Last Modified: 05 Feb 2019 19:15
URI: http://repository.essex.ac.uk/id/eprint/15073

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