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Genetic studies of body mass index yield new insights for obesity biology

Locke, AE and Kahali, B and Berndt, SI and Justice, AE and Pers, TH and Day, FR and Powell, C and Vedantam, S and Buchkovich, ML and Yang, J and Croteau-Chonka, DC and Esko, T and Fall, T and Ferreira, T and Gustafsson, S and Kutalik, Z and Luan, J and Mägi, R and Randall, JC and Winkler, TW and Wood, AR and Workalemahu, T and Faul, JD and Smith, JA and Zhao, JH and Zhao, W and Chen, J and Fehrmann, R and Hedman, ÅK and Karjalainen, J and Schmidt, EM and Absher, D and Amin, N and Anderson, D and Beekman, M and Bolton, JL and Bragg-Gresham, JL and Buyske, S and Demirkan, A and Deng, G and Ehret, GB and Feenstra, B and Feitosa, MF and Fischer, K and Goel, A and Gong, J and Jackson, AU and Kanoni, S and Kleber, ME and Kristiansson, K and Lim, U and Lotay, V and Mangino, M and Leach, IM and Medina-Gomez, C and Medland, SE and Nalls, MA and Palmer, CD and Pasko, D and Pechlivanis, S and Peters, MJ and Prokopenko, I and Shungin, D and Stančáková, A and Strawbridge, RJ (2015) 'Genetic studies of body mass index yield new insights for obesity biology.' Nature, 518 (7538). 197 - 206. ISSN 0028-0836

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Abstract

© 2015 Macmillan Publishers Limited. All rights reserved. Obesity is heritable and predisposes to many diseases. To understand the genetic basis of obesity better, here we conduct a genome-wide association study and Metabochip meta-analysis of body mass index (BMI), a measure commonly used to define obesity and assess adiposity, in up to 339,224 individuals. This analysis identifies 97 BMI-associated loci (P < 5 × 10 -8 ), 56 of which are novel. Five loci demonstrate clear evidence of several independent association signals, and many loci have significant effects on other metabolic phenotypes. The 97 loci account for ∼2.7% of BMI variation, and genome-wide estimates suggest that common variation accounts for > 20 % of BMI variation. Pathway analyses provide strong support for a role of the central nervous system in obesity susceptibility and implicate new genes and pathways, including those related to synaptic function, glutamate signalling, insulin secretion/action, energy metabolism, lipid biology and adipogenesis.

Item Type: Article
Subjects: H Social Sciences > H Social Sciences (General)
R Medicine > R Medicine (General)
Divisions: Faculty of Social Sciences > Institute for Social and Economic Research
Depositing User: Jim Jamieson
Date Deposited: 28 Sep 2015 11:06
Last Modified: 17 Aug 2017 17:32
URI: http://repository.essex.ac.uk/id/eprint/15075

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