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Computational limits to binary genes

Zabet, Nicolae Radu and Chu, Dominique F (2010) 'Computational limits to binary genes.' Journal of The Royal Society Interface, 7 (47). pp. 945-954. ISSN 1742-5689

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<jats:p>We analyse the trade-off between the speed with which a gene can propagate information, the noise of its output and its metabolic cost. Our main finding is that for any given level of metabolic cost there is an optimal trade-off between noise and processing speed. Any system with a non-vanishing leak expression rate is suboptimal, i.e. it will exhibit higher noise and/or slower speed than leak-free systems with the same metabolic cost. We also show that there is an optimal Hill coefficient<jats:italic>h</jats:italic>which minimizes noise and metabolic cost at fixed speeds, and an optimal threshold<jats:italic>K</jats:italic>which minimizes noise.</jats:p>

Item Type: Article
Uncontrolled Keywords: noise; speed; metabolic cost; trade-off
Subjects: Q Science > QC Physics
Q Science > QH Natural history > QH426 Genetics
Divisions: Faculty of Science and Health
Faculty of Science and Health > Life Sciences, School of
SWORD Depositor: Elements
Depositing User: Elements
Date Deposited: 17 Dec 2015 12:42
Last Modified: 18 Aug 2022 12:10

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