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Computational limits to binary genes

Zabet, NR and Chu, DF (2010) 'Computational limits to binary genes.' Journal of the Royal Society Interface, 7 (47). 945 - 954. ISSN 1742-5689

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Abstract

We analyse the trade-off between the speed with which a gene can propagate information, the noise of its output and its metabolic cost. Our main finding is that for any given level of metabolic cost there is an optimal trade-off between noise and processing speed. Any system with a non-vanishing leak expression rate is suboptimal, i.e. it will exhibit higher noise and/or slower speed than leak-free systems with the same metabolic cost.We also show that there is an optimal Hill coefficient h which minimizes noise and metabolic cost at fixed speeds, and an optimal threshold K which minimizes noise. © 2009 The Royal Society.

Item Type: Article
Subjects: Q Science > QC Physics
Q Science > QH Natural history > QH426 Genetics
Divisions: Faculty of Science and Health > Life Sciences, School of
Depositing User: Nicolae Zabet
Date Deposited: 17 Dec 2015 12:42
Last Modified: 07 Oct 2019 08:15
URI: http://repository.essex.ac.uk/id/eprint/15118

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