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A novel and versatile computational tool to model translation

Chu, D and Zabet, NR and von der Haar, T (2012) 'A novel and versatile computational tool to model translation.' Bioinformatics, 28 (2). pp. 292-293. ISSN 1367-4803

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Abstract

Motivation: Much is now known about the mechanistic details of gene translation. There are also rapid advances in high-throughput technologies to determine quantitative aspects of the system. As a consequence-realistic and system-wide simulation models of translation are now feasible. Such models are also needed as devices to integrate a large volume of highly fragmented data known about translation. Software: In this application note, we present a novel, highly efficient software tool to model translation. The tool represents the main aspects of translation. Features include a representation of exhaustible tRNA pools, ribosome–ribosome interactions and differential initiation rates for different mRNA species. The tool is written in Java, and is hence portable and can be parameterized for any organism.

Item Type: Article
Uncontrolled Keywords: Ribosomes; RNA, Messenger; Codon; RNA, Transfer; Protein Biosynthesis; Open Reading Frames; Software
Subjects: Q Science > QC Physics
Q Science > QH Natural history > QH301 Biology
Divisions: Faculty of Science and Health
Faculty of Science and Health > Life Sciences, School of
SWORD Depositor: Elements
Depositing User: Elements
Date Deposited: 03 Nov 2015 15:34
Last Modified: 18 Aug 2022 12:10
URI: http://repository.essex.ac.uk/id/eprint/15123

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