Chu, D and Zabet, NR and von der Haar, T (2012) A novel and versatile computational tool to model translation. Bioinformatics, 28 (2). pp. 292-293. DOI https://doi.org/10.1093/bioinformatics/btr650
Chu, D and Zabet, NR and von der Haar, T (2012) A novel and versatile computational tool to model translation. Bioinformatics, 28 (2). pp. 292-293. DOI https://doi.org/10.1093/bioinformatics/btr650
Chu, D and Zabet, NR and von der Haar, T (2012) A novel and versatile computational tool to model translation. Bioinformatics, 28 (2). pp. 292-293. DOI https://doi.org/10.1093/bioinformatics/btr650
Abstract
Motivation: Much is now known about the mechanistic details of gene translation. There are also rapid advances in high-throughput technologies to determine quantitative aspects of the system. As a consequence-realistic and system-wide simulation models of translation are now feasible. Such models are also needed as devices to integrate a large volume of highly fragmented data known about translation. Software: In this application note, we present a novel, highly efficient software tool to model translation. The tool represents the main aspects of translation. Features include a representation of exhaustible tRNA pools, ribosome–ribosome interactions and differential initiation rates for different mRNA species. The tool is written in Java, and is hence portable and can be parameterized for any organism.
Item Type: | Article |
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Uncontrolled Keywords: | Ribosomes; RNA, Messenger; Codon; RNA, Transfer; Protein Biosynthesis; Open Reading Frames; Software |
Subjects: | Q Science > QC Physics Q Science > QH Natural history > QH301 Biology |
Divisions: | Faculty of Science and Health Faculty of Science and Health > Life Sciences, School of |
SWORD Depositor: | Unnamed user with email elements@essex.ac.uk |
Depositing User: | Unnamed user with email elements@essex.ac.uk |
Date Deposited: | 03 Nov 2015 15:34 |
Last Modified: | 30 Oct 2024 16:10 |
URI: | http://repository.essex.ac.uk/id/eprint/15123 |