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The genomes of four tapeworm species reveal adaptations to parasitism

Tsai, IJ and Zarowiecki, M and Holroyd, N and Garciarrubio, A and Sanchez-Flores, A and Brooks, KL and Tracey, A and Bobes, RJ and Fragoso, G and Sciutto, E and Aslett, M and Beasley, H and Bennett, HM and Cai, J and Camicia, F and Clark, R and Cucher, M and De Silva, N and Day, TA and Deplazes, P and Estrada, K and Fernández, C and Holland, PWH and Hou, J and Hu, S and Huckvale, T and Hung, SS and Kamenetzky, L and Keane, JA and Kiss, F and Koziol, U and Lambert, O and Liu, K and Luo, X and Luo, Y and MacChiaroli, N and Nichol, S and Paps, J and Parkinson, J and Pouchkina-Stantcheva, N and Riddiford, N and Rosenzvit, M and Salinas, G and Wasmuth, JD and Zamanian, M and Zheng, Y and Cai, X and Soberón, X and Olson, PD and Laclette, JP and Brehm, K and Berriman, M and Morett, E and Portillo, T and Jose, MV and Carrero, JC and Larralde, C and Morales-Montor, J and Limon-Lason, J and Cevallos, MA and Gonzalez, V and Ochoa-Leyva, A and Landa, A and Jimenez, L and Valdes, V (2013) 'The genomes of four tapeworm species reveal adaptations to parasitism.' Nature, 496 (7443). 57 - 63. ISSN 0028-0836

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Abstract

Tapeworms (Cestoda) cause neglected diseases that can be fatal and are difficult to treat, owing to inefficient drugs. Here we present an analysis of tapeworm genome sequences using the human-infective species Echinococcus multilocularis, E. granulosus, Taenia solium and the laboratory model Hymenolepis microstoma as examples. The 115-to 141-megabase genomes offer insights into the evolution of parasitism. Synteny is maintained with distantly related blood flukes but we find extreme losses of genes and pathways that are ubiquitous in other animals, including 34 homeobox families and several determinants of stem cell fate. Tapeworms have specialized detoxification pathways, metabolism that is finely tuned to rely on nutrients scavenged from their hosts, and species-specific expansions of non-canonical heat shock proteins and families of known antigens. We identify new potential drug targets, including some on which existing pharmaceuticals may act. The genomes provide a rich resource to underpin the development of urgently needed treatments and control. © 2013 Macmillan Publishers Limited. All rights reserved.

Item Type: Article
Subjects: Q Science > QH Natural history > QH426 Genetics
Divisions: Faculty of Science and Health > Biological Sciences, School of
Depositing User: Jim Jamieson
Date Deposited: 07 Oct 2015 13:28
Last Modified: 14 Nov 2017 12:15
URI: http://repository.essex.ac.uk/id/eprint/15226

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