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The oyster genome reveals stress adaptation and complexity of shell formation

Wang, J and Zhang, G and Fang, X and Guo, X and Li, L and Luo, R and Xu, F and Yang, P and Zhang, L and Wang, X and Qi, H and Xiong, Z and Que, H and Xie, Y and Holland, PWH and Paps, J and Zhu, Y and Wu, F and Chen, Y and Wang, J and Peng, C and Meng, J and Yang, L and Liu, J and Wen, B and Zhang, N and Huang, Z and Zhu, Q and Feng, Y and Mount, A and Hedgecock, D and Xu, Z and Liu, Y and Domazet-Lošo, T and Du, Y and Sun, X and Zhang, S and Liu, B and Cheng, P and Jiang, X and Li, J and Fan, D and Wang, W and Fu, W and Wang, T and Wang, B and Zhang, J and Peng, Z and Li, Y and Li, N and Wang, J and Chen, M and He, Y and Tan, F and Song, X and Zheng, Q and Huang, R and Yang, H and Du, X and Chen, L and Yang, M and Gaffney, PM and Wang, S and Luo, L and She, Z and Ming, Y and Huang, W and Zhang, S and Huang, B and Zhang, Y and Qu, T and Ni, P and Miao, G and Wang, J and Wang, Q and Steinberg, CEW and Wang, H and Li, N and Qian, L and Zhang, G and Li, Y and Yang, H and Liu, X and Yin, Y and Wang, J (2012) 'The oyster genome reveals stress adaptation and complexity of shell formation.' Nature, 490 (7418). 49 - 54. ISSN 0028-0836

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Abstract

The Pacific oyster Crassostrea gigas belongs to one of the most species-rich but genomically poorly explored phyla, the Mollusca. Here we report the sequencing and assembly of the oyster genome using short reads and a fosmid-pooling strategy, along with transcriptomes of development and stress response and the proteome of the shell. The oyster genome is highly polymorphic and rich in repetitive sequences, with some transposable elements still actively shaping variation. Transcriptome studies reveal an extensive set of genes responding to environmental stress. The expansion of genes coding for heat shock protein 70 and inhibitors of apoptosis is probably central to the oyster's adaptation to sessile life in the highly stressful intertidal zone. Our analyses also show that shell formation in molluscs is more complex than currently understood and involves extensive participation of cells and their exosomes. The oyster genome sequence fills a void in our understanding of the Lophotrochozoa. © 2012 Macmillan Publishers Limited. All rights reserved.

Item Type: Article
Subjects: Q Science > QH Natural history > QH301 Biology
Q Science > QH Natural history > QH426 Genetics
Q Science > QL Zoology
Divisions: Faculty of Science and Health > Biological Sciences, School of
Depositing User: Jordi Paps Montserrat
Date Deposited: 14 Oct 2015 11:02
Last Modified: 17 Aug 2017 17:31
URI: http://repository.essex.ac.uk/id/eprint/15271

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