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New genes from old: Asymmetric divergence of gene duplicates and the evolution of development

Holland, PWH and Marlétaz, F and Maeso, I and Dunwell, TL and Paps, J (2017) 'New genes from old: Asymmetric divergence of gene duplicates and the evolution of development.' Philosophical Transactions of the Royal Society B: Biological Sciences, 372 (1713). ISSN 0962-8436

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Abstract

© 2016 The Author(s) Published by the Royal Society. All rights reserved. Gene duplications and gene losses have been frequent events in the evolution of animal genomes, with the balance between these two dynamic processes contributing to major differences in gene number between species. After gene duplication, it is common for both daughter genes to accumulate sequence change at approximately equal rates. In some cases, however, the accumulation of sequence change is highly uneven with one copy radically diverging from its paralogue. Such ‘asymmetric evolution’ seems commoner after tandem gene duplication than after whole-genome duplication, and can generate substantially novel genes. We describe examples of asymmetric evolution in duplicated homeobox genes of moths, molluscs and mammals, in each case generating new homeobox genes that were recruited to novel developmental roles. The prevalence of asymmetric divergence of gene duplicates has been underappreciated, in part, because the origin of highly divergent genes can be difficult to resolve using standard phylogenetic methods.

Item Type: Article
Subjects: Q Science > QH Natural history > QH426 Genetics
Q Science > QL Zoology
Divisions: Faculty of Science and Health > Biological Sciences, School of
Depositing User: Jordi Paps Montserrat
Date Deposited: 30 Jan 2017 16:58
Last Modified: 20 Dec 2017 02:00
URI: http://repository.essex.ac.uk/id/eprint/18789

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