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Nucleosomes in gene regulation: Theoretical approaches

Teif, VB and Shkrabkou, AV and Egorova, VP and Krot, VI (2012) 'Nucleosomes in gene regulation: Theoretical approaches.' Molecular Biology, 46 (1). 1 - 10. ISSN 0026-8933

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Abstract

This work reviews current theoretical approaches of biophysics and bioinformatics for the description of nucleosome arrangements in chromatin and transcription factor binding to nucleosomal organized DNA. The role of nucleosomes in gene regulation is discussed from the molecular-mechanistic and biological points of view. In addition to classical problems in this field, actual questions of epigenetic regulation are discussed. The authors selected for discussion what seem to be the most interesting concepts and hypotheses. Mathematical approaches are described in a simplified language to attract attention to the most important directions of this field.

Item Type: Article
Uncontrolled Keywords: nucleosome, chromatin, lattice models, competitive binding, transcription factors
Subjects: Q Science > QH Natural history > QH426 Genetics
Divisions: Faculty of Science and Health > Life Sciences, School of
Depositing User: Elements
Date Deposited: 16 Oct 2017 10:54
Last Modified: 02 Sep 2019 23:15
URI: http://repository.essex.ac.uk/id/eprint/20481

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